PhD Position on Anticancer Nanozymes to Fight Astrocytoma Relapse Empa in Switzerland

Empa, a leading research institution of the ETH Domain in Switzerland, is offering a PhD position focused on the development of anticancer nanozymes to combat astrocytoma relapse. The position is based in the Nanomaterials in Health Lab, an interdisciplinary environment renowned for pioneering research in nanomedicine, including personalized particle design for drug delivery, imaging, and diagnosis. The successful candidate will synthesize photoactive nanozymes, ensuring reproducibility and scalability, and modify their surface chemistry for enhanced biocompatibility and stability. The project also involves integrating nanozymes into clinically relevant formulations, characterizing their physicochemical properties, and correlating enzymatic activities with nanomaterial structure and functionalization. Phototherapy evaluation under NIR light and assessment of catalytic and photothermal performance are key components, alongside biomedical validation using in vitro astrocytoma relapse models and ex vivo patient-derived tissue samples.

The position is supported by Empa and supervised by Dr. Giacomo Reina, in collaboration with PD Dr. Isabel Hostettler (Kantonsspital St. Gallen) and with joint affiliation to ETH Zürich (D-HEST, Prof. Peter Wick). The project is planned for three years with the possibility of extension and will be carried out as a fully funded PhD thesis. Applicants should hold a Master’s degree in biomaterials, chemistry, nanotechnology, or biomedical engineering, and possess experience in nanomaterial synthesis and characterization. Familiarity with cell culture, 3D models, and in vitro assays is required, while experience in phototherapy, programming, and large data analysis is advantageous. Fluency in English and excellent communication skills are essential.

Empa fosters a culture of inclusion and respect, welcoming applicants interested in innovative, sustainable, and meaningful research. The desired starting date is May 1, 2026, or upon mutual agreement. Applications must be submitted online via the Empa job portal, including a letter of motivation, CV, certificates, diplomas, and contact details of two referees. Applications by e-mail or post will not be considered.