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International PhD Programme (IPP) Mainz, Institute of Molecular Biology

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PhD Position: Synthetic Cells that Transcribe: Active Transcriptional Condensates in DNA Protonuclei International PhD Programme Mainz, Institute of Molecular Biology in Germany

Degree Level

PhD

Field of study

Chemistry

Funding

Available

Deadline

Oct 15, 2026

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Country

Germany

University

International PhD Programme (IPP) Mainz, Institute of Molecular Biology

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Keywords

Chemistry
Biology
Molecular Dynamics
Microscopy
Synthetic Biology
Chemical Biology
Transcriptional Regulation
Dna Nanotechnology
Protein Phosphorylation

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About this position

The International PhD Programme (IPP) Mainz at the Institute of Molecular Biology is offering a fully funded PhD position in an interdisciplinary project on synthetic cells, transcriptional condensates, and DNA protonuclei.

The project is hosted by the research group of Andreas Walther in collaboration with Jan Padeken, with additional interaction with Lukas Stelzl, and forms part of the CRC/SFB 1551 on polymer concepts in cellular function. The work sits at the interface of DNA nanoscience, synthetic biology, chemical biology, and systems chemistry, with connections to molecular simulations and in vivo experiments.

Scientific focus: the successful candidate will build DNA-based synthetic cells and DNA protonuclei that allow genes, polymerases, and enzymes to be positioned with molecular precision. Using a chimeric T7::CTD polymerase, the project will investigate how transcription and condensate organisation influence each other. Planned work includes designing barcoded and multi-compartment protonuclei, measuring transcription and condensate dynamics, and testing how the CTD, transcription factors, and kinases/phosphatases tune output and RNA feedback.

Methods and training include transcription assays, confocal microscopy, FRAP, molecular design, and quantitative analysis in an international English-speaking environment. The programme offers advanced training in scientific techniques and professional skills, access to state-of-the-art core facilities, and a lively community of PhD researchers.

Eligibility highlights: applicants should hold a Master’s degree or equivalent in Molecular Biology, Synthetic Biology, Chemical Biology, Biochemistry, or Chemistry, have a good command of English, and provide two letters of reference. Experience with nucleic acids, enzymes, protein purification, or quantitative microscopy is advantageous.

Funding: the position is described as fully funded with financing until completion of the thesis, although the CRC/SFB component is noted as pending third-party funding support.

Application deadline: 15 October 2026. Interviews are planned for 18–19 January 2027 at IMB Mainz. The intended start date is between 1 February and 31 July 2027. Applicants are instructed to select Walther as their group preference in the IPP application platform and apply via the online form on the IMB PhD application website.

Funding details

Available

What's required

Applicants should have a Master’s degree or equivalent in Molecular Biology, Synthetic Biology, Chemical Biology, Biochemistry, or Chemistry, with a very good academic record. A good command of English and an interactive personality are required, along with two letters of reference. Experience with nucleic acids, enzymes, protein purification, or quantitative microscopy is considered a plus.

How to apply

Select Walther as your group preference in the IPP application platform. Submit your application via the online form at the IMB PhD apply website and include the required references. Applications are due by 15 October 2026; interviews will be held at IMB in Mainz on 18–19 January 2027.

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