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University Hospital Heidelberg

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PhD Student or Postdoc in Computational Biology for NR2F1 Neurodevelopment and Cortical Circuit Formation Heidelberg University Hospital in Germany

Degree Level

PhD, Postdoc

Field of study

Computer Science

Funding

Full funding available

Deadline

Aug 31, 2026

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Country

Germany

University

University Hospital Heidelberg

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Keywords

Computer Science
Biomedical Engineering
Biology
Computational Biology
Neuropsychology
Transcriptional Regulation
Neurodevelopment
Omics
Epigenetic
Developmental Neuroscience
Genomic
Statistics
Bioinformatic
Transcriptomic

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About this position

Heidelberg University Hospital (Institute of Human Genetics, AG Laugsch) is hiring for a PhD Student or Postdoc in Computational Biology to investigate how NR2F1 dosage shapes neurodevelopment and cortical circuit formation.

The project sits at the intersection of bioinformatics, computational biology, neuroscience, gene regulation, genomics, transcriptomics, epigenomics, and multi-omics. The research uses CRISPR/Cas9-engineered human iPSCs, 2D cell lineages, and 3D forebrain dorsal organoids, with time-resolved bulk data (RNA-seq, ATAC-seq, ChIP-seq, Hi-C) and single-cell datasets (scRNA-seq, scATAC-seq, Multiome).

Responsibilities include building computational pipelines for single-cell multi-omics analysis, reconstructing gene regulatory networks in organoids, integrating new and public omics datasets in HPC environments, and designing an interactive open-access web platform for visualization.

Applicants should hold a Master's or PhD in Bioinformatics, Computational Biology, Data Science, or a related field. Strong skills in R or Python, shell scripting, omics pipeline development, and HPC are expected. Interest in gene regulation, epigenomics, or developmental neuroscience is important; prior gene regulatory network inference experience is a plus. Excellent written and spoken English is required.

The position is a 3-year fixed-term contract on the TV-L E13 salary scale. Benefits mentioned include 30 days vacation, company pension (VBL), job ticket, family-friendly childcare support, and health/sports programs.

The work location is Heidelberg, Germany. The application deadline is 31 August 2026. Apply online via the provided link and contact Dr. rer. nat. Magdalena Laugsch by email for further information.

Funding details

Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.

How to apply

Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.

More information can be found here

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