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The Francis Crick Institute

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Postdoc in Structural Biology and TGF-β Signalling at The Francis Crick Institute The Francis Crick Institute in United Kingdom

Degree Level

Postdoc

Field of study

Biochemistry

Funding

Available

Deadline

Sep 30, 2026

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Country

United Kingdom

University

The Francis Crick Institute

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Keywords

Biochemistry
Molecular Biology
Biomedical Engineering
Biophysics
Biology
Crystallography
Structural Biology
Cryo-electron Microscopy
Cancer

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About this position

The Francis Crick Institute in London, United Kingdom is recruiting a Postdoc in the Hill Lab led by Caroline Hill. The project sits at the intersection of structural biology, Cryo-EM, crystallography, biochemistry, biophysics, and molecular biology, with a strong focus on TGF-β family signalling, SMAD complexes, and developmental signalling in health and disease.

The lab studies how TGF-β family signalling pathways function in early vertebrate development and adult cells, and how they are altered in disease, including cancer and Marfan-related syndromes. The advertised postdoc will work on structural projects to understand how the SKI–phosphorylated SMAD2–SMAD4 complex is recognised by RNF111 for proteasomal degradation, and how activated SMAD complexes bind TGF-β/activin-responsive elements with cooperating transcription factors to activate transcription. The work also includes disease-relevant questions in Myhre syndrome.

Applicants should have a PhD in a relevant biological science, ideally structural biology, plus demonstrated experience with Cryo-EM and crystallography. The role also asks for technical expertise in molecular biology, protein production, biophysical and biochemical methods, and structural analysis, along with a strong publication record and evidence of presenting research at scientific meetings.

This is a full-time postdoctoral position at Europe’s largest biomedical research institute under one roof. The deadline shown on the post is 30 Sep 2026. To apply, use the job’s Apply button / jobs.ac.uk application page and review the full job description before submitting.

Funding details

Available

What's required

PhD in a relevant biological science, ideally structural biology. Good knowledge and experience of Cryo-EM and crystallography. Technical expertise in molecular biology, protein production, biophysical and biochemical techniques, and structural analysis. Track record of writing papers evidenced by publications or submitted manuscripts in refereed journals. Strong evidence of data presentation at scientific meetings. Strong organisational skills, thorough record-keeping, and ability to work independently and in a team.

How to apply

Click the Apply button on the job page to submit an application. Review the full job description before applying.

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