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German Cancer Research Center

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Postdoc in Structural Biology of Protein Kinase Regulation by RNA Helicases German Cancer Research Center in the Helmholtz Association in Germany

Degree Level

Postdoc

Field of study

Biochemistry

Funding

Postdoc position remunerated according to TV-L, including occupational pension plan and capital-forming payments. The position is initially limited to 2 years with the possibility of prolongation.

Deadline

Sep 9, 2026

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Country

Germany

University

German Cancer Research Center

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Keywords

Biochemistry
Chemistry
Biomedical Engineering
Biophysics
Biology
Crystallography
Structural Biology
Cryo-electron Microscopy
Protein Purification
Medical Science
Cancer Therapy
Wnt Signaling

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About this position

Postdoctoral opening in structural biology at the German Cancer Research Center (DKFZ) in Heidelberg, Germany, focused on the regulation of protein kinases by RNA helicases in the context of Wnt signaling and cancer biology.

The project, led by Prof. Dr. Christof Niehrs in collaboration with Prof. Dr. Irmgard Sinning at the University of Heidelberg, aims to determine how the DEAD-box RNA helicase DDX3X activates CK1. The successful candidate will produce recombinant proteins, purify and characterize protein complexes, and analyze their 3D structure using cryo-EM single-particle analysis and/or X-ray crystallography.

Relevant techniques include recombinant protein production, FPLC, Western blotting, automated crystallization, HDX-MS, MST, ITC, AI-assisted protein modeling, and synchrotron-based structure determination. The postdoc will primarily work in the Sinning lab and receive training in advanced structural biochemistry and biophysics.

Applicants should have a master’s degree in molecular life sciences such as biochemistry, biotechnology, or molecular biology, with experience in recombinant protein work and/or structural biology. Strong independence, collaboration skills, and good English communication are required.

The position is initially for 2 years with possible extension. Salary is according to TV-L, including occupational pension plan and capital-forming payments. Additional benefits include 30 days of vacation, flexible working hours, part-time options, family-friendly conditions, subsidized Germany job ticket, health management support, and access to DKFZ postdoc/career services.

Application deadline: 2026-09-09. Apply online only; email applications are not accepted. Submit a single PDF with CV, cover letter, certificates, expected availability date, publication list, and two reference letters.

Funding details

Postdoc position remunerated according to TV-L, including occupational pension plan and capital-forming payments. The position is initially limited to 2 years with the possibility of prolongation.

What's required

Applicants should hold a master's degree in molecular life sciences such as biochemistry, biotechnology, or molecular biology, with a background in recombinant protein work and/or structural biology. Candidates must be able to work independently and collaboratively, and have good written and oral English skills.

How to apply

Submit a single PDF application including CV, cover letter with research and career interests, certificates, expected availability date, and publication list, plus two letters of reference. Apply via the website only; applications by email are not accepted.

More information can be found here

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