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Wright State University

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Postdoctoral Fellow in Medicinal Chemistry and Drug Discovery at Wayne State University Wayne State University in United States

Degree Level

Postdoc

Field of study

Chemistry

Funding

Full funding available
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Country

United States

University

Wright State University

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Keywords

Chemistry
Biomedical Engineering
Organic Chemistry
Biology
Chemical Biology
Medical Science
Pharmacy
Pharmaceutical Chemistry
Pharmacokinetic

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About this position

Wayne State University is recruiting a Postdoctoral Fellow in Medicinal Chemistry and Drug Discovery at its Detroit campus in the United States. The position is based in the Fehl Lab in the Department of Chemistry and focuses on medicinal chemistry, drug discovery, chemical biology, and organic chemistry.

The project centers on O-GlcNAc transferase (OGT), a high-value target linked to cancer, diabetes, and obesity. The lab has new NIH grants supporting chemical tool development and metabolic disease research, and the postdoc will help advance a rationally designed hit compound from bench to preclinical study. Work includes designing and synthesizing small-molecule OGT inhibitors, building structure-activity relationships (SAR), developing radical/photochemical synthetic methods, evaluating potency/selectivity/mechanism in vitro and in cells, and optimizing pharmacokinetic properties such as solubility, metabolic stability, and permeability.

This is a translational, high-impact opportunity with exposure to publications, patents, and possible commercialization pathways, including Wayne State’s TechTown startup environment. The posting emphasizes a supportive and collaborative lab culture, mentorship from PI Charlie Fehl, and opportunities to work with disease biologists and mentor junior trainees.

Eligibility highlights: a PhD in organic chemistry, medicinal chemistry, or a related field is preferred; applicants should have hands-on experience with small-molecule inhibitor synthesis and evaluation, interest in chemical method development, and strong communication and teamwork skills. Interest in translational science, biotech, or startups is also preferred.

Funding: full-time employee role with annual salary compensation; salary range is USD 55,000 to 63,480.

How to apply: use the Wayne State University careers portal and click Apply Now. The posting does not list a separate deadline.

Funding details

Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.

How to apply

Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.

More information can be found here

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