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University of Dundee

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Postdoctoral Research Assistant in Synthetic Medicinal Chemistry / Chemical Biology for Targeted Protein Degradation and Mitochondrial Probe Discovery University of Dundee in United Kingdom

Degree Level

Postdoc

Field of study

Chemistry

Funding

Fixed-term postdoctoral appointment for 18 months from 1 September 2026. The post is described as part of an ambitious, well-funded multi-institutional programme; no stipend or salary amount is stated in the post.

Deadline

Sep 21, 2026

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Country

United Kingdom

University

University of Dundee

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Keywords

Chemistry
Biology
Chemical Synthesis
Chemical Biology
Pharmacy

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About this position

Postdoctoral Research Assistant opportunity in synthetic medicinal chemistry / chemical biology at the University of Dundee, within the Centre for Targeted Protein Degradation (CeTPD) and the CONTROL-MITO team.

The project focuses on designing, synthesising, and characterising novel chemical probes to induce protein–protein proximity in the mitochondrial matrix. The work sits in an interdisciplinary network involving the University of Glasgow and the University of Edinburgh, and includes collaboration with biophysicists, structural biologists, cell biologists, and mitochondrial biologists.

Research themes and keywords include linker chemistry, bifunctional probes, PROTACs, molecular glues, targeted protein degradation, mitochondrial chemistry, structure-based drug design, and fragment-based drug design. The role uses an iterative DMTA cycle and involves biophysical assays such as SPR, TR-FRET, AlphaLISA, ITC, and NanoBRET, plus analytical chemistry methods including HPLC-MS and NMR.

Eligibility highlights: a PhD in organic chemistry, medicinal chemistry, chemical biology, or a closely related field; strong synthetic route design and multi-step synthesis experience; an excellent publication record; and familiarity with proximity-inducing chemical biology tools such as degron tags, CIP systems, BromoTag, dTAG, HaloTag, or AID.

Funding/contract: fixed-term appointment for 18 months starting 1 September 2026. The post is described as part of a well-funded multi-institutional programme, but no salary or stipend amount is given.

Deadline: 21 September 2026.

How to apply: follow the jobs.ac.uk application link and submit through the portal. For questions, contact Professor Alessio Ciulli ([email protected]) or Dr Will Farnaby ([email protected]).

Funding details

Fixed-term postdoctoral appointment for 18 months from 1 September 2026. The post is described as part of an ambitious, well-funded multi-institutional programme; no stipend or salary amount is stated in the post.

What's required

A PhD in organic chemistry, medicinal chemistry, chemical biology, or a closely related discipline is required. Applicants should have an outstanding academic track record, at least one co-authored publication in an internationally recognised peer-reviewed journal, strong hands-on expertise in organic synthesis and synthetic route design including multi-step synthesis of complex small molecules, and desirable experience with PROTACs, molecular glues, heterobifunctional probes, structure-based or fragment-based drug design, and related proximity-inducing chemical biology tools.

How to apply

Use the View or Apply link to open the jobs.ac.uk application page and submit an application there. For informal enquiries, contact Professor Alessio Ciulli or Dr Will Farnaby by email.

More information can be found here

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