Postdoctoral Researcher in Experimental Neurodegeneration University of Luxembourg in Luxembourg

Postdoctoral Researcher in Experimental Neurodegeneration at the University of Luxembourg, Luxembourg Centre for Systems Biomedicine (LCSB).

This postdoctoral position sits within an interdisciplinary, international research environment focused on systems biomedicine, neurodegenerative disease, and translational biology. The project targets experimental neurodegeneration with a particular interest in Alzheimer’s and Parkinson’s disease and their contributing factors. The successful candidate will lead iPSC-based experimental work and connect it to broader cellular, mitochondrial, and bioinformatics analyses in collaboration with a multidisciplinary consortium.

The role involves maintaining patient-derived and isogenic-control induced pluripotent stem cell (iPSC) lines, differentiating them into midbrain dopaminergic and cholinergic neuronal models, and contributing to organoid experiments. You will plan and perform longitudinal perturbation studies on intracellular calcium signalling, mitochondrial calcium handling, and CHCHD-family expression. Methods include siRNA knockdown, plasmid or viral-vector overexpression, rescue experiments, immunocytochemistry, Western blotting, high-content imaging, live-cell calcium imaging, multielectrode-array recordings, single-cell RNA sequencing sample preparation, proteomics, metabolomics, electron microscopy, and Seahorse extracellular flux experiments.

The position is ideal for candidates with strong hands-on experience in mammalian cell culture, especially human iPSC culture and neuronal differentiation, plus experience in molecular perturbation, fluorescence microscopy, image analysis, mitochondrial biology, and calcium signalling. Familiarity with single-cell sequencing, multiomics, organoids, electrophysiology, or EM workflows is an advantage. The role also includes data analysis using rigorous statistical and reproducible workflows, coordination across work packages and partner institutions, presentation at consortium meetings and international conferences, manuscript preparation, and support for students and technical staff.

Eligibility highlights include a PhD in neuroscience, neurobiology, cell biology, molecular biology, biomedicine, stem-cell biology, or a closely related discipline, along with a strong publication record appropriate to career stage. English at professional C1 level is expected. The University of Luxembourg offers a modern, multilingual, and inclusive environment with high-quality infrastructure and strong links to professional sectors and international partners.

Employment is a fixed-term, full-time contract for 36 months. The advertised gross yearly salary for a Postdoctoral Researcher at the University of Luxembourg is EUR 87,306. Applications are reviewed as they arrive, so early submission is recommended. Apply online via the HR system and do not use email for submission.