PhD in Transcellular Propagation of Tauopathies at the University of Cambridge University of Cambridge in United Kingdom

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Targeting Immune Cell Trafficking to Treat Neurological Disorders . This project focuses on inflammatory peripheral neuropathies , where the immune system attacks peripheral nerves and causes weakness, numbness, pain, and impaired mobility. The research aims to identify whether a specific immune-cell trafficking pathway drives immune-cell accumulation in affected nerves and whether blocking this pathway...

PhD opportunity in neuroscience at the University of St Andrews focused on prediction-error plasticity , synaptic mechanisms , cerebellar learning , and inferior olive circuitry . The project asks where learning-related changes occur in the brain: at inputs to olive neurons, within the olive cells themselves, or at the synapses connecting to the cerebellum. Using larval zebrafish , the student will map sensory and motor pathways, then combine multiple techniques to observe synaptic changes durin...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Mitochondrial Genetic Determinants of Multiple Sclerosis . This project investigates how mitochondrial genetic variants influence the outcome of multiple sclerosis (MS) . The research builds on prior genome-wide association studies (GWAS) that have identified more than 200 autosomal variants associated with MS, while extending the analysis to the mitochondrial genome. Using a dedicated mitochondrial var...

PhD studentship opportunity at the University of Exeter through the SWBio DTP Hub Doctoral Training Partnership. The project is led by Wendy Noble, with co-supervision from Robert Williams (University of Bath), Rosie Bamford, and Clémence Bernard. It will investigate the expression and function of novel tau isoforms in the healthy and diseased brain, and their potential contribution to dementia. This is a strong opportunity for candidates interested in neuroscience, dementia research, neurodegen...