Postdoctoral Researcher in Precision Medicine, Single-Cell Genomics and Immunology for Juvenile Idiopathic Arthritis Institut Imagine in France

Postdoctoral Researcher in Precision Medicine for Juvenile Idiopathic Arthritis at Institut Imagine, INSERM, Université Paris Cité in Paris, France.

The SCInflaNet lab is recruiting a postdoc to lead the SMART-JIA project at the intersection of single-cell genomics, functional immunology, and AI-driven precision medicine. The project focuses on why anti-TNF therapy fails in some children with juvenile idiopathic arthritis (JIA) and how treatment failure might be predicted before therapy starts.

The research builds on scRNA-seq findings from PBMCs of JIA patients and aims to validate transcriptomic signatures as a predictive SMART-Score, dissect mechanisms of anti-TNF resistance, and cross-validate findings in biologic-naïve adult rheumatoid arthritis patients. The work includes single-cell multi-omics (10x Multiome, scRNA-seq, scATAC-seq), ex vivo functional assays, biomarker validation, and algorithm development, with close collaboration with clinicians at Necker and Cochin Hospitals.

Eligibility highlights include a PhD in Immunology, Cell Biology, Molecular Biology, or a related field, experience with flow cytometry/cell sorting, functional immunology, primary human immune cells from clinical cohorts, and familiarity with single-cell omics (10x Genomics). A background in autoimmunity, R/Python, and a strong publication record are advantageous.

The position starts in 2026 (ASAP) and is offered for 2 years, renewable, with a competitive salary, mentoring, career development, and access to clinical cohorts, biobanks, and world-class platforms at Single-Cell@Imagine.

To apply, send a single PDF by email to [email protected] including a cover letter, CV with publications, a 1-page research summary, and 2–3 referee contacts. Applications are reviewed on a rolling basis until filled.