PhD Position in DNA Replication and Cancer Genetics at Karolinska Institutet

Karolinska Institutet in Solna, Sweden, is offering a fully funded PhD position in the research group of Assistant Professor Bennie Lemmens, focusing on DNA replication mechanisms and cancer genetics. The Lemmens group, established in 2021, is part of the Science for Life Laboratory (SciLifeLab) and the Genome Biology division at the Department of Medical Biochemistry and Biophysics. The lab investigates how human cells copy DNA, maintain genome stability, and applies this knowledge to design better, more selective anti-cancer treatments. The PhD project centers on defining how human cells initiate DNA replication and discovering new strategies to improve cancer care. The research involves creating human cell models using advanced protein depletion and CRISPR-based genome modification techniques, studied with cutting-edge imaging and single-cell analysis platforms. The student will gain hands-on experience in cell culture, RNAi, CRISPR-editing, immunofluorescence microscopy, and both fixed and live-cell imaging. Automated microscopy and image analysis will be key tools for analyzing different cell types and treatments. The position offers a creative and inspiring environment, with access to a dynamic team of scientists, international collaborations, and a wide range of elective courses. Karolinska Institutet is renowned for its medical research and education, providing opportunities for international exchanges and personal development. The successful candidate will be employed on a full-time doctoral studentship for up to four years, with a monthly salary and additional benefits such as free gym access and medical care reimbursements. Eligibility requirements include a master's degree in molecular medicine, biomedicine, or an equivalent field, or completion of at least 240 credits with 60 at the master's level. Proficiency in English equivalent to Swedish upper secondary school English B/English 6 is required. Experience with gene technology, CRISPR methods, and fluorescence microscopy is considered a merit. Applicants should be highly motivated, enthusiastic, possess innovative thinking, strong organizational skills, and be able to work both independently and in a team. Excellent communication skills in English are required. Applications must be submitted via the Varbi recruitment system by January 1, 2026. Required documents include a personal letter, CV, degree projects, publications, and documents certifying eligibility. For more information, visit the research group page and the official job posting.