Christian Ottmann

University Name

Netherlands

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Articles (21)

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Article Link

Year:

2025

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Article Link

Year:

2025

Identifying 14-3-3 interactome binding sites with deep learning

Article Link

Year:

2025

Proximity-enhanced cysteine–histidine crosslinking for elucidating intrinsically disordered and other protein complexes

Article Link

Year:

2025

Site-specific molecular glues for the 14-3-3/Tau pS214 protein–protein interaction via reversible covalent imine tethering

Article Link

Year:

2025

14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization

Article Link

Year:

2024

14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation

Article Link

Year:

2024

Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment

Article Link

Year:

2024

Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ

Article Link

Year:

2024

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

Article Link

Year:

2023

A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers

Article Link

Year:

2023

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

Article Link

Year:

2023

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking

Article Link

Year:

2023

Crystal structure and ligandability of the 14-3-3/pyrin interface

Article Link

Year:

2023

A simple method for developing lysine targeted covalent protein reagents

Article Link

Year:

2023

Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3

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Year:

2022

Fragment-based exploration of the 14-3-3/Amot-p130 interface

Article Link

Year:

2022

Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study

Article Link

Year:

2022

Molecular glues to stabilise protein–protein interactions

Article Link

Year:

2022

Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition

Article Link

Year:

2022

Challenges of studying 14-3-3 protein-protein interactions with full-length protein partners

Article Link

Year:

2022

Collaborators (10)

Martine Smit

University of Amsterdam

NETHERLANDS

Michelle R. Arkin

University of California

UNITED STATES

Luc Brunsveld

Prof. at Eindhoven University of Technology

Eindhoven University of Technology

NETHERLANDS

Andrew J. Wilson

UNITED KINGDOM

Mireille M. A. E. Claessens

University of Twente

NETHERLANDS

Adam Renslo

Professor

University of California, San Francisco

UNITED STATES

Markella Konstantinidou

University of California, San Francisco

UNITED STATES

Peter Cossar

Eindhoven University of Technology

NETHERLANDS

Arjan Hazegh Nikroo

Eindhoven University of Technology

NETHERLANDS

Christian Blum

University of Twente

NETHERLANDS

Christian Ottmann

Research Interests

Explore related searches

Contact this professor

Articles (21)

Scaffold-hopping for molecular glues targeting the 14-3-3/ERα complex

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Identifying 14-3-3 interactome binding sites with deep learning

Proximity-enhanced cysteine–histidine crosslinking for elucidating intrinsically disordered and other protein complexes

Site-specific molecular glues for the 14-3-3/Tau pS214 protein–protein interaction via reversible covalent imine tethering

14‐3‐3 Protein‐Protein Interactions: From Mechanistic Understanding to Their Small‐Molecule Stabilization

14-3-3τ as a Modulator of Early α-Synuclein Multimerization and Amyloid Formation

Discovery of 14‐3‐3 PPI Stabilizers by Extension of an Amidine‐Substituted Thiophene Fragment

Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ

Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments

A Systematic Approach to the Discovery of Protein–Protein Interaction Stabilizers

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

From Tethered to Freestanding Stabilizers of 14‐3‐3 Protein‐Protein Interactions through Fragment Linking

Crystal structure and ligandability of the 14-3-3/pyrin interface

A simple method for developing lysine targeted covalent protein reagents

Fusicoccin-A Targets Cancerous Inhibitor of Protein Phosphatase 2A by Stabilizing a C-Terminal Interaction with 14-3-3

Fragment-based exploration of the 14-3-3/Amot-p130 interface

Understanding the interaction of 14‐3‐3 proteins with hDMX and hDM2: a structural and biophysical study

Molecular glues to stabilise protein–protein interactions

Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition

Challenges of studying 14-3-3 protein-protein interactions with full-length protein partners

Collaborators (10)

Martine Smit

Michelle R. Arkin

Luc Brunsveld

Andrew J. Wilson

Mireille M. A. E. Claessens

Adam Renslo

Markella Konstantinidou

Peter Cossar

Arjan Hazegh Nikroo

Christian Blum

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