Christoph Nitsche

Australian National University

Australia

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Articles (20)

Biocompatible strategies for peptide macrocyclisation

The identification of macrocyclic peptides in drug discovery demands not only advanced screening strategies but also robust and reliable synthetic methodologies to constrain peptides under biocompatible conditions.

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Year:

2024

(2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5′-Difluoroleucine in Escherichia coli PpiB: Protein Production, 19F NMR, and Ligand Sensing Enhanced by the γ-Gauche Effect

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Year:

2024

Conformational Preferences of the Non-Canonical Amino Acids (2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5′-Difluoroleucine in a Protein

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Year:

2024

Cell‐Penetrating Peptide‐Bismuth Bicycles**

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Year:

2024

Characterisation of ten NS2B-NS3 proteases

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Year:

2024

Exploring biocompatible chemistry to create stapled and photoswitchable variants of the antimicrobial peptide aurein 1.2

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Year:

2024

Bicyclic peptides

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Year:

2024

A RaPID Response to SARS-CoV-2

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Year:

2024

Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems

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Year:

2023

Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis

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Year:

2023

Paramagnetic Chemical Probes for Studying Biological Macromolecules

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Year:

2022

Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction

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Year:

2022

Peptide–Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity

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Year:

2022

Antiviral cyclic peptides targeting the main protease of SARS-CoV-2

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Year:

2022

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir

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Year:

2022

Organoarsenic probes to study proteins by NMR spectroscopy

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Year:

2022

2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

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Year:

2021

Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals.

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Year:

2021

A biocompatible stapling reaction for: In situ generation of constrained peptides

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Year:

2021

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors

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Year:

2021

Collaborators (7)

Gottfried Otting

Australian National University

AUSTRALIA

Anupriya Aggarwal

UNSW Sydney

AUSTRALIA

Marcellus Ubbink

Leiden University

NETHERLANDS

Nitin Patil

MONASH UNIVERSITY

AUSTRALIA

Jörg Rademann

Freie Universität Berlin

GERMANY

Pritha Ghosh

The Australian National University

AUSTRALIA

Thomas Huber

Professor

Australian National University

AUSTRALIA

Christoph Nitsche

Research Interests

Explore related searches

Contact this professor

Articles (20)

Biocompatible strategies for peptide macrocyclisation

(2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5′-Difluoroleucine in Escherichia coli PpiB: Protein Production, 19F NMR, and Ligand Sensing Enhanced by the γ-Gauche Effect

Conformational Preferences of the Non-Canonical Amino Acids (2S,4S)-5-Fluoroleucine, (2S,4R)-5-Fluoroleucine, and 5,5′-Difluoroleucine in a Protein

Cell‐Penetrating Peptide‐Bismuth Bicycles**

Characterisation of ten NS2B-NS3 proteases

Exploring biocompatible chemistry to create stapled and photoswitchable variants of the antimicrobial peptide aurein 1.2

Bicyclic peptides

A RaPID Response to SARS-CoV-2

Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems

Selective thiazoline peptide cyclisation compatible with mRNA display and efficient synthesis

Paramagnetic Chemical Probes for Studying Biological Macromolecules

Genetic Encoding of Cyanopyridylalanine for In‐Cell Protein Macrocyclization by the Nitrile–Aminothiol Click Reaction

Peptide–Bismuth Bicycles: In Situ Access to Stable Constrained Peptides with Superior Bioactivity

Antiviral cyclic peptides targeting the main protease of SARS-CoV-2

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir

Organoarsenic probes to study proteins by NMR spectroscopy

2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease

Nanoparticular Inhibitors of Flavivirus Proteases from Zika, West Nile and Dengue Virus Are Cell-Permeable Antivirals.

A biocompatible stapling reaction for: In situ generation of constrained peptides

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors

Collaborators (7)

Gottfried Otting

Anupriya Aggarwal

Marcellus Ubbink

Nitin Patil

Jörg Rademann

Pritha Ghosh

Thomas Huber

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