Frans Russel

Professor and Chair

Radboud University Medical Center

Netherlands

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Frans Russel is a Professor and Chair at Radboud University Medical Center, Netherlands. His research focuses on mitochondrial transport proteins, drug-induced mitochondrial toxicity, and the role of transporters in drug metabolism, particularly in pediatric therapies. Recent publications include studies on the effects of allopurinol and febuxostat, the cellular impact of statins on cardiomyocytes, and the pharmacokinetics of various drugs related to chronic conditions.

Frans Russel

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Articles (15)

Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells

Unlocking mitochondrial drug targets: The importance of mitochondrial transport proteins

Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification

Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells

Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity

Physiologically-Based Pharmacokinetic Modelling to Predict the Pharmacokinetics and Pharmacodynamics of Linezolid in Adults and Children with Tuberculous Meningitis

Transporter-Mediated Cellular Distribution of Tyrosine Kinase Inhibitors as a Potential Resistance Mechanism in Chronic Myeloid Leukemia

Statins and Cardiomyocyte Metabolism, Friend or Foe?

Determination of cytotoxicity following oxidative treatment of pharmaceutical residues in wastewater

Application of proteomics to understand maturation of drug metabolizing enzymes and transporters for the optimization of pediatric drug therapy

Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling

Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

Toxicity of anticancer drugs in human placental tissue explants and trophoblast cell lines

Completing the Enalaprilat Excretion Pathway—Renal Handling by the Proximal Tubule

Collaborators (5)

Nico P.E. Vermeulen

Tom Schirris

Werner J.H. Koopman

W. F. L. M. Hoeben

Elin Svensson

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