Leen 't Hart

AssociateProfessor

Leiden University Medical Center

Netherlands

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Leen 't Hart is an Associate Professor at Leiden University Medical Center in the Netherlands. His research primarily focuses on type 2 diabetes, including the role of small non-coding RNAs, clinical characteristics, and complications associated with the disease. He has published articles exploring genetic factors, metabolic implications, and the identification of subgroups within type 2 diabetes to inform treatment strategies.

Leen 't Hart

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Articles (16)

Circulating small non‐coding RNAs are associated with the insulin‐resistant and obesity‐related type 2 diabetes clusters

Branched‐chain amino acid levels are inversely associated with incident and prevalent chronic kidney disease in people with type 2 diabetes

Trajectories of clinical characteristics, complications and treatment choices in data-driven subgroups of type 2 diabetes

Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and Macrovascular Complications of Type 2 Diabetes

Small RNA sequencing reveals snoRNAs and piRNA-019825 as novel players in diabetic kidney disease

Potential Value of Identifying Type 2 Diabetes Subgroups for Guiding Intensive Treatment: A Comparison of Novel Data-Driven Clustering With Risk-Driven Subgroups

Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study

Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids

Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT

Distinct Molecular Signatures of Clinical Clusters in People With Type 2 Diabetes

Replication and cross-validation of type 2 diabetes subtypes based on clinical variables

The power of genetic diversity in genome-wide association studies of lipids.

Genome-Wide Meta-analysis Identifies Genetic Variants Associated With Glycemic Response to Sulfonylureas.

Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes

Performance of prediction models for nephropathy in people with type 2 diabetes: systematic review and external validation study.

Long RNA Sequencing and Ribosome Profiling of Inflamed β-Cells Reveal an Extensive Translatome Landscape.

Collaborators (22)

sailalitha bollepalli

Konstantinos Tsirigos

Roel Bijkerk

Struan Grant

Nuno Zilhao

Ewan Pearson

Noha Yousri

Eric Sijbrands

Xinyu Li

Anton Jan van Zonneveld

Stavroula Kanoni

Louis Perusse

Federico De Masi

Jette Bork-Jensen

esteban J parra

Alicia Huerta-Chagoya

James Altunkaya

Anu-Maria Loukola

Mathias Gerl

Timothy Pullen

Harriet Teare

Julia Ramirez

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