Marek Basler

The Biozentrum at the University of Basel is inviting applications for a fully funded PhD position in the research group of Prof. Marek Basler. The project focuses on the function and regulation of the bacterial Type 6 secretion system (T6SS), a large dynamic contractile nanomachine used by Gram-negative bacteria to deliver proteins across membranes and interact with neighboring bacterial or eukaryotic cells. This PhD project sits at the intersection of molecular microbiology, protein biochemistry, bacterial cell biology, and related areas such as protein-protein interactions, bacterial signaling, imaging, and infection biology. The central scientific goal is to understand how T6SS assembly is controlled, how it is spatially positioned within bacterial cells, and how the timing of firing is regulated in response to environmental or cellular signals. The project builds on recent discoveries showing that T6SS localization and activation can depend on cell-contact sites, membrane damage sensing, and host-associated conditions, but the precise mechanisms remain unknown. The successful candidate will join a highly interactive, multidisciplinary, and international research environment at one of the world’s leading life sciences institutes. The Biozentrum offers strong support through specialized core facilities in imaging, biophysics, and electron microscopy, together with a structured PhD program and broad opportunities for training, scientific exchange, and networking. Eligibility highlights include an MSc degree with a research thesis in molecular microbiology, protein biochemistry, protein-protein interactions, electron microscopy, bacterial signaling, or a related discipline. Prior practical experience with live-cell imaging is considered an advantage. The position is based in Basel, Switzerland, a highly international city at the meeting point of Switzerland, Germany, and France. Applications must be submitted through the online application form. Candidates should provide a brief statement describing their research experience and motivation for the position, a full CV, and contact details for at least two academic references. Review of applications begins in September and continues until the position is filled. Informal inquiries may be directed to Prof. Marek Basler at [email protected].

PhD opening at the Biozentrum, University of Basel, in the research group of Prof. Marek Basler. The project focuses on the Type 6 secretion system (T6SS) in Gram-negative bacteria, with an emphasis on the molecular mechanisms that control its assembly, spatial localization, and firing timing. The work sits at the intersection of molecular microbiology , protein biochemistry , bacterial cell biology , protein-protein interactions , bacterial signaling , and potentially live-cell imaging and electron microscopy . The position is described as fully funded and embedded in a highly interactive, multidisciplinary, international research environment. The Biozentrum offers structured PhD training, networking, scientific exchange, and access to specialized core facilities including Imaging, Biophysics, and Electron Microscopy. Applicants should hold an MSc degree with a research thesis in molecular microbiology, protein biochemistry, protein-protein interactions, electron microscopy, bacterial signaling, or a related field. Prior hands-on experience with live-cell imaging is an advantage. The position starts immediately or by mutual agreement. Applications are submitted exclusively via the online application form. Required materials include a brief statement of research experience and motivation, a CV, and contact details for at least two academic references. Review begins in September and continues until the position is filled. Location: Basel, Switzerland.