Mattia Zampieri

The Zampieri Lab at the University of Basel, led by Professor Mattia Zampieri, is seeking motivated students and researchers for Bachelor’s, Master’s, PhD, and postdoctoral positions. The lab specializes in computational biology, metabolomics, systems biology, and antimicrobial discovery, offering a unique opportunity to work with unpublished, large-scale metabolomics datasets. Research projects focus on monitoring chemical and genetic perturbations in systems such as tuberculosis, E. coli, and cancer cells, providing hands-on experience with cutting-edge data and impactful biological questions. Current openings include Bachelor’s and Master’s projects at the interface of experimental and computational biology, as well as funded PhD and postdoctoral positions in quantitative and systems biology. The lab encourages applications from highly motivated individuals with backgrounds in biology, biochemistry, computational analysis, or related fields. Applicants should possess strong communication skills and a collaborative mindset. For PhD and postdoc roles, relevant degrees and research experience are required. Funding is available for PhD and postdoctoral positions, with application through the University of Basel Jobportal. Bachelor’s and Master’s projects are typically for academic credit or internships, with funding details not explicitly stated. The application deadline for all positions is December 28, 2025. Interested candidates should visit the Zampieri Lab website, review open positions, and follow the application instructions provided. Keywords: computational biology, metabolomics, systems biology, antimicrobial discovery, biochemistry, genetic perturbations, cancer biology, tuberculosis, E. coli, large-scale data analysis.

The Zampieri Lab at the University of Basel is offering a PhD position in Systems Biology and Cancer Metabolism. This opportunity is ideal for candidates interested in understanding how metabolic programs drive cancer metastasis. The research project integrates in vivo mouse models, CRISPR-engineered cancer cell lines, pooled CRISPR screens, high-throughput metabolomics, and computational data analysis within a systems biology framework. The lab provides a dynamic, interdisciplinary environment with access to state-of-the-art facilities and strong mentorship, situated in one of Europe’s leading life science hubs. Applicants should possess a Master’s degree in a relevant field and have hands-on experience with mouse models, including LTK-1 certification. A strong interest in cancer metabolism and quantitative approaches is essential. Experience with CRISPR, metabolomics, and computational biology is highly valued. The position offers the chance to work at the intersection of biology, medical science, and computational analysis, contributing to cutting-edge research in cancer biology. While specific funding details are not provided, PhD positions at the University of Basel are typically funded. Interested candidates must submit their applications through the official recruiting system of the University of Basel. Only applications submitted via this system will be considered. For more information about the lab and the research focus, candidates can refer to the LinkedIn profile of Professor Mattia Zampieri. Keywords: Systems Biology, Cancer Metabolism, Metabolomics, CRISPR, Computational Biology, Biochemistry, Mouse Models.

The Zampieri Lab at the University of Basel is offering a PhD position focused on the systems biology of cancer metastasis. This opportunity is situated within the Department of Biomedicine, the largest department at the University, which unites basic and clinical scientists to advance health research and develop innovative therapies. The research group specializes in systems pharmacology, computational biology, and metabolic regulation, aiming to uncover mechanisms of metabolic adaptation in response to genetic and chemical perturbations, with the goal of identifying new therapeutic strategies for cancer and other diseases. The successful candidate will work on a project investigating how metabolic programs enable cancer cells to metastasize and colonize distant tissues, using advanced mouse models and in close collaboration with the Bentires Lab. The project is fundamentally experimental, requiring hands-on in vivo mouse work, including tumor models, animal handling, injections, tissue collection, and monitoring. High-throughput metabolic profiling, computational data analysis, and next-generation sequencing (NGS) of pooled CRISPR libraries are integral parts of the research, providing a systems-level approach to understanding cancer metabolism. Applicants must have a Master's degree in a relevant field such as (Bio-)Physics, (Bio-)Engineering, Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, or Bioinformatics/Computational Biology. Documented hands-on experience with in vivo mouse experiments and LTK-1 certification are essential. Additional desirable skills include experience with intracardiac injections, bioluminescence imaging, and proficiency in programming languages like MATLAB, R, or Python. Excellent communication skills and motivation to work in an international, interdisciplinary environment are required. The Department of Biomedicine offers access to cutting-edge facilities, including mouse laboratories, high-end FACS, IT and microscopy resources, and the Life Sciences Training Facility for gene expression and proteome profiling. The candidate will join a dynamic team of computer scientists, experimentalists, and clinicians, with opportunities for cross-disciplinary collaboration and professional development. The University of Basel is committed to diversity, inclusion, and equal opportunities in its working and learning environment. To apply, candidates should submit a cover letter, CV, and the PhD application form via the University of Basel Recruiting-Portal, as detailed on the Zampieri Lab website. For more information about the lab and application process, visit zampierilab.org/join-us/ .