PhD Position in Systems Biology of Cancer Metastasis at University of Basel University of Basel in Switzerland

The Zampieri Lab at the University of Basel is offering a PhD position focused on the systems biology of cancer metastasis. This opportunity is situated within the Department of Biomedicine, the largest department at the University, which unites basic and clinical scientists to advance health research and develop innovative therapies. The research group specializes in systems pharmacology, computational biology, and metabolic regulation, aiming to uncover mechanisms of metabolic adaptation in response to genetic and chemical perturbations, with the goal of identifying new therapeutic strategies for cancer and other diseases.

The successful candidate will work on a project investigating how metabolic programs enable cancer cells to metastasize and colonize distant tissues, using advanced mouse models and in close collaboration with the Bentires Lab. The project is fundamentally experimental, requiring hands-on in vivo mouse work, including tumor models, animal handling, injections, tissue collection, and monitoring. High-throughput metabolic profiling, computational data analysis, and next-generation sequencing (NGS) of pooled CRISPR libraries are integral parts of the research, providing a systems-level approach to understanding cancer metabolism.

Applicants must have a Master's degree in a relevant field such as (Bio-)Physics, (Bio-)Engineering, Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, or Bioinformatics/Computational Biology. Documented hands-on experience with in vivo mouse experiments and LTK-1 certification are essential. Additional desirable skills include experience with intracardiac injections, bioluminescence imaging, and proficiency in programming languages like MATLAB, R, or Python. Excellent communication skills and motivation to work in an international, interdisciplinary environment are required.

The Department of Biomedicine offers access to cutting-edge facilities, including mouse laboratories, high-end FACS, IT and microscopy resources, and the Life Sciences Training Facility for gene expression and proteome profiling. The candidate will join a dynamic team of computer scientists, experimentalists, and clinicians, with opportunities for cross-disciplinary collaboration and professional development. The University of Basel is committed to diversity, inclusion, and equal opportunities in its working and learning environment.

To apply, candidates should submit a cover letter, CV, and the PhD application form via the University of Basel Recruiting-Portal, as detailed on the Zampieri Lab website. For more information about the lab and application process, visit zampierilab.org/join-us/.