Nishit Goradia

Goradia Lab is launching at the International Institute of Molecular Mechanisms and Machines (IMol), Warsaw, and is recruiting founding members for two openings: a PhD student and a postdoctoral researcher. The lab’s research programme focuses on SLiM multivalency , higher-order protein assembly , transcriptional regulation , chromatin states , and cancer biology . The group will study how repeated short linear motifs encode assembly behaviour, reorganise transcriptional regulators, and influence cell fate. The post highlights a recent Nature Communications finding on tandem ALDLS motifs in RAI2 engaging CtBP and driving polymerisation, nuclear foci formation, and relief of transcriptional repression. PhD project: investigates how multivalent SLiM-mediated interactions control CtBP assemblies and nuclear foci, with training in molecular and cell biology, quantitative imaging, protein biochemistry, and proteomic/functional-genomic approaches. Postdoctoral project: examines how SLiM multivalency-driven CtBP assembly alters transcriptional and chromatin states using RNA-seq, ATAC-seq, ChIP-based methods, multi-omics integration, and targeted functional validation in cancer cell models. The post invites curious, collaborative, and motivated scientists to help shape a new interdisciplinary programme. Expressions of interest and informal enquiries are welcome, and the official IMol recruitment calls with deadlines will be published soon through the institute’s recruitment process. Contact: [email protected]