Othon Moultos

PI at Delft University of Technology

Delft University of Technology
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Netherlands

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Positions (1)

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Othon Moultos

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Delft University of Technology

PhD Position: Design of Plant-Based Dairy Alternatives Using Molecular Modeling

This PhD position at Delft University of Technology (TU Delft) offers the opportunity to join the HARMONY project, which aims to develop the next generation of plant-based dairy alternatives using advanced molecular modeling techniques. The successful candidate will be embedded in the Process & Energy department of the Mechanical Engineering Faculty and will collaborate with researchers from Wageningen University & Research (WUR) and industrial partners. The project addresses the challenge of replicating the structure and texture of dairy foods using plant-based ingredients, focusing on creating compounds that mimic the mouthfeel and sensory properties of traditional dairy. The HARMONY project, funded by the Dutch Research Council (NWO), combines experimental and simulation approaches to understand and design the physicochemical and sensory properties of new food compounds. The research is expected to have a transformative impact on the field of food science and plant-based product development. TU Delft is a leading international university known for its strengths in science, engineering, and design, and offers a vibrant, diverse, and supportive research environment. The Mechanical Engineering Faculty is dynamic and innovative, with state-of-the-art laboratory facilities and a strong focus on interdisciplinary research. The PhD position is a full-time, fixed-term contract for four years, with an initial one-year appointment and the possibility of renewal for three additional years based on satisfactory progress. The position includes a competitive salary starting at €2,770 gross per month in the first year and rising to €3,539 in the fourth year, along with an 8% holiday allowance and an 8.3% year-end bonus. A comprehensive PhD training programme is included. The ideal candidate will have a strong background in mechanical, chemical, or materials engineering, physics, or chemistry, with proven skills in scientific computing and programming. Excellent English communication skills, a collaborative attitude, and the ability to work independently are essential. Prior experience with molecular simulation or modeling is a plus but not required. Applicants must submit a CV, cover letter, and a list of academic grades as a single PDF. The application deadline is 21 November 2025. TU Delft provides support for international candidates relocating to the Netherlands, including assistance with settling in and dual career support for partners. The university values diversity and inclusion and is committed to providing a welcoming environment for all researchers.

9 months ago

Articles (18)

Ultrasound enhanced diffusion in hydrogels: An experimental and non-equilibrium molecular dynamics study

Focused ultrasound has experimentally been found to enhance the diffusion of nanoparticles; our aim with this work is to study this effect closer using both experiments and non-equilibrium molecular dynamics. Measurements from single particle tracking of 40 nm polystyrene nanoparticles in an agarose hydrogel with and without focused ultrasound are presented and compared with a previous experimental study using 100 nm polystyrene nanoparticles. In both cases, we observed an increase in the mean square displacement during focused ultrasound treatment. We developed a coarse-grained non-equilibrium molecular dynamics model with an implicit solvent to investigate the increase in the mean square displacement and its frequency and amplitude dependencies. This model consists of polymer fibers and two sizes of nanoparticles, and the effect of the focused ultrasound was modeled as an external oscillating force field. A comparison between the simulation and experimental results shows similar mean square displacement trends, suggesting that the particle velocity is a significant contributor to the observed ultrasound-enhanced mean square displacement. The resulting diffusion coefficients from the model are compared to the diffusion equation for a two-time continuous time random walk. The model is found to have the same frequency dependency. At lower particle velocity amplitude values, the model has a quadratic relation with the particle velocity amplitude as described by the two-time continuous time random walk derived diffusion equation, but at higher amplitudes, the model deviates, and its diffusion coefficient reaches the non-hindered diffusion coefficient. This observation suggests that at higher ultrasound intensities in hydrogels, the non-hindered diffusion coefficient can be used.

Year:

2024

Collaborators (12)

Carlos Vega

Full Professor

Universidad Complutense de Madrid

SPAIN

Hadi Hajibeygi

Associate Professor

TU Delft

NETHERLANDS

Mahinder Ramdin

Delft University of Technology

NETHERLANDS

Erika Eiser

Professor

-

NORWAY

Romain PRIVAT

Université de Lorraine

FRANCE

Jean‐Noël Jaubert

Université de Lorraine

FRANCE

Anders Lervik

-

NORWAY

Costas Vlahos

University of Ioannina

GREECE

Poulumi Dey

-

NETHERLANDS

Johan Padding

Prof. at Delft University of Technology

Delft University of Technology

NETHERLANDS

Silvia Lasala

Assistant professor

-

FRANCE

Thijs J. H. Vlugt

Delft University of Technology

NETHERLANDS
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