Shahram Kordasti

Fully funded 4-year PhD opportunity in cancer immunotherapy and cell engineering through the Cancer Research UK City of London Centre PhD Programme . The project focuses on engineering shielded, bone marrow homing regulatory T cells (Tregs) for hypoplastic myelodysplastic neoplasms . The research aims to develop next-generation engineered Tregs that can survive the inflammatory bone marrow environment and preferentially localise to the marrow. Key scientific themes include T cell engineering , cancer immunology , gene circuits , flow cytometry , functional assays , and preclinical models . The project will combine FAS resistance, hypoxia-responsive CXCR4 expression, and inducible IL-10 to test whether engineered Tregs can suppress pathogenic immune responses while protecting residual haematopoiesis. Primary supervisor: Shahram Kordasti , King’s College London . Secondary supervisor: Sara Ghorashian , University College London . Potential placements include the Francis Crick Institute and collaborating groups at King’s College London. The programme provides a fully funded 4-year PhD with a stipend of £25,074 in year 1 , increasing annually, plus access to a broad network of scientific and clinical researchers across central London. Applications are now open for an Autumn 2027 start. Apply using the programme links provided in the post.