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Shahram Kordasti

1 week ago

Fully Funded PhD in Cancer Immunotherapy and Cell Engineering for Hypoplastic Myelodysplastic Neoplasms King's College London in United Kingdom

Degree Level

PhD

Field of study

Immunotherapy

Funding

Fully funded 4-year PhD through the Cancer Research UK City of London Centre PhD Programme. Stipend is £25,074 in year 1 and increases annually. Access to a broad network of scientific and clinical researchers across central London is included.

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Country

United Kingdom

University

King's College London

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Keywords

Immunotherapy
Biomedical Engineering
Hematology
Biology
Medical Science
Regulatory T Cells

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About this position

Fully funded 4-year PhD opportunity in cancer immunotherapy and cell engineering through the Cancer Research UK City of London Centre PhD Programme.

The project focuses on engineering shielded, bone marrow homing regulatory T cells (Tregs) for hypoplastic myelodysplastic neoplasms. The research aims to develop next-generation engineered Tregs that can survive the inflammatory bone marrow environment and preferentially localise to the marrow.

Key scientific themes include T cell engineering, cancer immunology, gene circuits, flow cytometry, functional assays, and preclinical models. The project will combine FAS resistance, hypoxia-responsive CXCR4 expression, and inducible IL-10 to test whether engineered Tregs can suppress pathogenic immune responses while protecting residual haematopoiesis.

Primary supervisor: Shahram Kordasti, King’s College London. Secondary supervisor: Sara Ghorashian, University College London. Potential placements include the Francis Crick Institute and collaborating groups at King’s College London.

The programme provides a fully funded 4-year PhD with a stipend of £25,074 in year 1, increasing annually, plus access to a broad network of scientific and clinical researchers across central London.

Applications are now open for an Autumn 2027 start.

Apply using the programme links provided in the post.

Funding details

Fully funded 4-year PhD through the Cancer Research UK City of London Centre PhD Programme. Stipend is £25,074 in year 1 and increases annually. Access to a broad network of scientific and clinical researchers across central London is included.

What's required

Applicants should be interested in cancer immunotherapy, cell engineering, T cell engineering, gene circuits, flow cytometry, functional assays, and preclinical models. The project is highly translational and suited to candidates with an interest in haematology and immune cell therapy.

How to apply

Review the programme details and application information via the provided links. Submit an application for the Cancer Research UK City of London Centre PhD Programme once ready. Share the opportunity with interested candidates if appropriate.

More information can be found here

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