Multiphoton Imaging for High-Throughput Crystallization Screening

This postdoctoral research position at KU Leuven focuses on developing and validating advanced multiphoton imaging strategies for high-throughput crystallization screening in pharmaceutical materials. The project is embedded within the Molecular Imaging and Photonics (MIP) group at KU Leuven KULAK (Kortrijk campus), an internationally oriented team specializing in nonlinear and multiphoton optical spectroscopy and microscopy for molecular and materials characterization. The MIP group operates state-of-the-art laser and optical infrastructure, including femtosecond laser systems and advanced nonlinear microscopy platforms, providing a supportive environment with hands-on training and opportunities for mentoring and co-supervision of PhD and Master’s students. The research aims to explore polarization-resolved third-harmonic generation (THG) as a universal, label-free probe for detecting trace crystallinity, advancing complementary harmonic imaging (CHI) by combining polarization-resolved SHG and THG to access structural information beyond conventional bulk analytical techniques. The project will also investigate widefield THG imaging concepts for high-throughput crystallization screening, offering clear academic novelty and opportunities for high-impact scientific publications. Collaboration with the Division of Drug Delivery and Pharmaceutical Analysis at KU Leuven ensures access to expertise in pharmaceutical solid-state analysis and formulation characterization, while active industrial involvement from partners in the pharmaceutical and photonics sectors supports technology development and valorization activities. Applicants must hold a PhD in Physics, Photonics, Optical Engineering, Physical Chemistry, or a closely related field, with a strong experimental background in nonlinear and/or multiphoton optics. Experience with harmonic generation, multiphoton microscopy, ultrafast laser–based techniques, and quantitative analysis of imaging data (e.g. Python, MATLAB) is highly valued. Candidates should demonstrate proven experience in building and critically evaluating optical experiments, solid understanding of optical imaging and polarization optics, and the ability to work independently at a postdoctoral level. Good scientific communication skills in English and a track record of first-author publications are expected. The position offers a full-time contract for two years, starting with an initial 1-year appointment and possible extension after positive evaluation. KU Leuven provides a competitive salary in accordance with postdoctoral salary scales and Belgian employment conditions, along with a comprehensive benefits package including holiday allowance, hospital insurance, commuting support, and access to university sports and cultural facilities at reduced rates. The research environment is highly collaborative, with opportunities to engage in adjacent nonlinear-optical and crystallization projects within the broader MIP programme and to interact with academic and industrial partners. Applications are evaluated as received and the position remains open until a suitable candidate is appointed. For more information, contact Prof. dr. Stijn Van Cleuvenbergen at [email protected]. KU Leuven is committed to diversity, inclusion, and equal opportunity, fostering an ambitious and respectful research and educational environment.