Toby Lawrence

This PhD studentship at the Centre d'Immunologie Marseille Luminy (INSERM) in France provides an outstanding opportunity to explore the intricate interactions between immune cells and the tumor microenvironment using advanced single-cell analysis and spatial proteogenomics. The successful candidate will develop and implement experimental workflows for high-dimensional data acquisition and apply state-of-the-art bioinformatics tools to analyze complex, multidimensional datasets. The research will leverage sophisticated mouse genetic models of cancer, conditional gene targeting, single-cell RNA sequencing, spectral flow cytometry, multiplex imaging, and spatial genomics to dissect the immunological and molecular profiles of tissues and cells from animal models of cancer. The project aims to generate mechanistic insights in collaboration with computational biologists and to investigate the functional immunological status of cancers and their microenvironments. The student will be responsible for establishing protocols for sample collection and analysis, maintaining accurate records and databases, and contributing to the research initiatives of the team and the Centre. The position is full-time, based in Marseille, and offers a fixed-term contract of 36 months with the possibility of a 12-month extension. Applicants should hold a Master's degree in biological sciences or a related field, have experience with experimental mouse models in immunology or oncology, and be familiar with single-cell omics technologies. Good English proficiency is required. The application deadline is December 1, 2025, and the position is expected to start on January 1, 2026. For further details, candidates can visit the lab's academic page or contact Dr. Toby Lawrence directly via email.

The Centre d’Immunologie Marseille-Luminy (CIML), a renowned European immunology research institute, is recruiting a Postdoctoral Research Associate for the Lawrence lab, which specializes in the immunobiology of macrophages and dendritic cells, particularly in the context of cancer. The project, funded by the Wellcome Trust, aims to unravel the mechanisms that regulate the dynamics and functional polarization of tumor-associated macrophages and dendritic cells. Utilizing genetically modified mouse models and conditional gene targeting, the successful candidate will employ advanced high-dimensional single-cell analysis technologies and spatial proteogenomics to investigate the complex interaction networks between immune cells and the tumor microenvironment. The role involves developing experimental workflows for data acquisition, applying bioinformatics tools to analyze multidimensional datasets, and collaborating with computational biologists to derive mechanistic insights. Techniques such as single-cell RNA-seq, spectral flow cytometry, multiplex imaging, and spatial genomics will be central to the research. The post holder will also contribute to grant writing, manuscript preparation, and broader research initiatives within the team and the Centre. CIML provides a vibrant, international research environment with cutting-edge core facilities, including advanced flow cytometry, bioimaging, genomics, mouse transgenics, and computational biology platforms. Located in the Luminy Science and Technology Park in Marseille, France, adjacent to the Parc National des Calanques, CIML is home to 185 scientists, students, and postdocs across 15 research groups. Applicants should possess a PhD in biological sciences or a related field, have substantial experience with experimental mouse models in immunology or oncology, and demonstrate proficiency in single cell omics technologies. A strong publication record, good command of English, and 1-4 years of relevant research experience are essential. The position is a full-time, fixed-term contract for 24 months, with the possibility of renewal. Applications should include a CV, cover letter, and relevant publications, and be sent to Dr. Toby Lawrence at [email protected]. For further details, candidates are encouraged to visit the lab website.