Publisher
source

University of Cambridge

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Studentship

PhD studentship in mechanisms of resistance to KRAS inhibition in pancreatic cancer University of Cambridge in United Kingdom

Degree Level

PhD

Field of study

Cancer Biology

Funding

Available

Deadline

Oct 16, 2026

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Country

United Kingdom

University

University of Cambridge

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Keywords

Cancer Biology
Biology
Medical Science
Tumor Microenvironment
Pancreatic Cancer
Fibroblast Biology
Mouse Model
Spatial Transcriptomic

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About this position

PhD studentship at the University of Cambridge / Cancer Research UK Cambridge Institute on mechanisms of resistance to KRAS inhibition in pancreatic cancer.

Supervisor: Dr Giulia Biffi (Biffi Lab). The project focuses on pancreatic ductal adenocarcinoma (PDAC), malignant-stromal crosstalk, cancer-associated fibroblasts, and how genetic heterogeneity shapes response and resistance to KRAS inhibitors.

Research approaches may include organoid co-transplantation in mouse models, in vivo CRISPR, single-cell RNA sequencing, flow cytometry, multiplex immunofluorescence, spatial transcriptomics, and standard molecular biology. A computational component may also be available depending on the student’s skills and interests.

Eligibility highlights: prior laboratory or industry research experience is required; willingness to work with mouse models throughout the PhD is essential; experience with tissue culture, organoids, immunohistochemistry, western blotting, PCR, and mouse work is preferred. Applicants from the UK and overseas are welcome.

Deadline: 16 October 2026. Start date: 1 October 2027. Apply via the University Applicant Portal and quote reference SW51012.

Funding details

Available

What's required

Applicants should be motivated and enthusiastic about collaborative cancer research. Prior experience in a laboratory or industry research environment is required. Willingness to work extensively with mouse models throughout the PhD is essential. Experience with tissue culture, cell lines and/or organoids, immunohistochemistry, western blotting and/or PCR, and mouse work is preferred. Knowledge or experience in pancreatic cancer or cancer biology would be advantageous. Applications are welcomed from UK and overseas students.

How to apply

Apply through the University of Cambridge Applicant Portal and select the October 2027 start date. Quote reference SW51012 in your application and any correspondence.

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