Doctoral Position: Gene Expression Regulation (f/m/x) University of Cologne in Germany

The University of Cologne is advertising a doctoral position in Gene Expression Regulation in the Uhlirova Lab at the Institute for Genetics within CECAD. The project sits at the interface of genetics, molecular and cell biology, systems-level analysis, and bioinformatics, with a strong focus on how stress-inducible signaling pathways control gene expression and influence tissue homeostasis and longevity.

The research environment is highly interdisciplinary. The lab combines functional genetics in Drosophila and mouse models with molecular and cell biology, multi-omics, advanced microscopy, and computational analysis. The successful doctoral candidate will investigate the crosstalk between transcription and pre-mRNA splicing under physiological, stress, and disease conditions; mechanisms underlying spliceosome assembly and functional plasticity; why certain transcripts, cells, and tissues are especially sensitive to aberrant splicing; and how spliceosome malfunction contributes to loss of tissue homeostasis, premature aging, and disease.

This position is designed for a highly motivated and curious PhD candidate who wants to lead an independent research project while contributing to collaborative work in an international team. The position offers access to state-of-the-art research facilities, an interactive working environment, extensive advanced training opportunities, occupational health management, and flexible working time models. The university also highlights equal opportunities and diversity and encourages applications from all suitably qualified candidates.

Applicants should have a completed Master’s degree or equivalent in Biology, Biochemistry, Biophysics, or a related life sciences field. A strong background in genetics and molecular/cell biology is essential, as is excellent English communication and a demonstrated ability to conduct independent research. Experience with model organisms, especially Drosophila and/or mouse and cell culture, is preferred. Additional strengths such as multi-omics, protein purification, biomolecular interaction assays, computational modeling, and quantitative image analysis are desirable.

The position is available immediately, is part-time (25.89 hours per week), and is funded for three years. Compensation is based on TV-L remuneration group 13 in the German public sector. The application deadline is 27 September 2026. Applications must be submitted online through the University of Cologne job portal with a cover letter, academic CV including publication list and three references, and copies of degree and qualification certificates. The reference number is Wiss2608-13.