Publisher
source

MRC Laboratory of Medical Sciences

Funded PhD in Designing Peptides to Uncover Cancer Vulnerabilities at Telomeres MRC Laboratory of Medical Sciences in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

Funded PhD studentship covering all tuition fees and a tax-free stipend of £26,500 per year paid monthly. Funding is available for both Home and Overseas students.

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Country

United Kingdom

University

MRC Laboratory of Medical Sciences

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Keywords

Cell Biology
Molecular Biology
Chemistry
Cancer Biology
Biology
Protein Chemistry
Chemical Synthesis
Telomere Biology
Pharmaceutical Chemistry

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About this position

Funded PhD project in telomere biology, cancer biology, peptide design, protein biochemistry, molecular biology, cell biology, and synthetic/pharmaceutical chemistry at the MRC Laboratory of Medical Sciences and Imperial College London in London, United Kingdom.

The project asks how cells replicate chromosome ends while preserving telomere protection. You will study the shelterin complex, TRF2 interactions, and the origin recognition complex (ORC), with a focus on how disrupting these interactions may expose cancer-cell vulnerabilities. A particular emphasis is on ALT (alternative lengthening of telomeres) cancers, comparing ALT cells, telomerase-positive cancer cells, and normal cells.

Research activities include mapping protein-protein interactions using purified human proteins, quantitative binding measurements, peptide design and synthesis, peptide optimisation, computational modelling, and experiments in human cells. The project connects molecular design with cell biology and imaging, and offers training across multiple disciplines.

Supervision is provided by Prof Christian Speck, Dr Anna Barnard, and Dr A Barr. The labs are based nearby in west London, enabling close collaboration across teams.

This is a funded PhD studentship covering full tuition fees plus a tax-free stipend of £26,500 per year. Funding is available for both Home and Overseas students.

Applicants from biochemistry, chemistry, molecular biology, or related disciplines are encouraged to apply. Prior experience in every technique is not required. Apply via the LMS studentships webpage; the FindAPhD register-interest form is not the application.

Funding details

Funded PhD studentship covering all tuition fees and a tax-free stipend of £26,500 per year paid monthly. Funding is available for both Home and Overseas students.

What's required

Applicants from biochemistry, chemistry, molecular biology or related disciplines are welcome. Prior experience across protein biochemistry, peptide design and synthesis, computational modelling, or quantitative cell imaging is not required, but interest in interdisciplinary research on telomeres and cancer is expected.

How to apply

Follow the application instructions on the LMS studentships webpage and submit an application form there. Registering interest on FindAPhD is not considered an application.

More information can be found here

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