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source

The Francis Crick Institute

Funded PhD in developmental robustness and congenital eye defects The Francis Crick Institute in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

Funded PhD project. Successful applicants will receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.

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Country

United Kingdom

University

The Francis Crick Institute

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Keywords

Molecular Biology
Biomedical Engineering
Biology
Developmental Biology
Neuropsychology
Medical Science
Mechanobiology
Extracellular Matrix Biology
Zebrafish Biology
Genetic
Computational Modelling

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About this position

Funded PhD opportunity at The Francis Crick Institute with Dr Stephen Wilson.

This project investigates developmental biology, genetics, zebrafish, eye formation, retinal morphogenesis, extracellular matrix, and mechanobiology. The research asks why congenital defects of eye formation show variable penetrance and severity, and how developmental robustness influences whether defects appear in one or both eyes.

The student will use CRISPR-based screening to identify genes that modulate robustness of eye formation, with an initial focus on interactions between the extracellular matrix and retinal pigment epithelium. The project also explores how Yap and ECM together maintain structural integrity during optic vesicle rearrangements, combining molecular genetics with high-resolution 4D imaging and potentially computational modelling.

Funding: a non-taxable annual stipend of £27,715 plus university tuition fees.

Eligibility: students of all nationalities may apply. The ideal candidate will have a background in developmental biology, genetics of model systems, or tissue mechanobiology, and an interest in imaging and complex in vivo developmental events.

Location: London, United Kingdom.

Project theme: congenital eye defects, developmental robustness, zebrafish genetics, mechanobiology, and morphogenesis.

Funding details

Funded PhD project. Successful applicants will receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.

What's required

Applicants should have a background in developmental biology, genetics of model systems, and/or tissue mechanobiology. Interest in molecular genetics and high-resolution 4D imaging approaches is important. Experience or interest in mechanobiology and possibly computational modelling would be advantageous.

How to apply

Review the project details and apply through the FindAPhD/Crick PhD application route. Prepare an application highlighting relevant experience in developmental biology, genetics, imaging, mechanobiology, or computational modelling.

More information can be found here

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