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Babraham Institute

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PhD in Spatial Control of Wnt–ERK Signalling by Glypican-Dependent Ligand Dispersal in Development and Disease Babraham Institute in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

Competition funded studentship (unfunded). Applicants must apply for their own funding; possible sources mentioned include University of Cambridge-wide funding competitions such as Gates Cambridge Trust and Cambridge Trust.

Deadline

Dec 8, 2027

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Country

United Kingdom

University

Babraham Institute

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Keywords

Molecular Biology
Biology
Developmental Biology
Neuropsychology
Medical Science
Neurodevelopment
Neurodegenerative Disease
Genetic
Wnt Signaling

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About this position

PhD opportunity: Spatial Control of Wnt–ERK Signalling by Glypican-Dependent Ligand Dispersal in Development and Disease at the Babraham Institute (Cambridge), with the Babraham Institute Graduate Programme and BitBio.

This project explores how glypicans regulate extracellular signalling environments, focusing on GPC6, Wnt ligand dispersal, ERK activation, and non-canonical Wnt pathway activity. The research connects developmental biology, genetics, molecular biology, and neuroscience, with relevance to skeletal dysplasia, schizophrenia, Parkinson’s disease, and neurodevelopmental/neurodegenerative mechanisms.

The student will investigate signalling in the developing mouse brain, especially dopaminergic neuron specification and patterning, and will also use iPSC-derived neurons and astrocytes to test whether similar mechanisms operate in human cells. A particular emphasis is placed on small GTPase-mediated signalling and downstream cellular responses such as neuronal maturation, neurite outgrowth, cytoskeletal organisation, and synaptic connectivity.

Supervisor: Dr Ian McGough (Babraham Institute). Email: [email protected].

Funding: Competition funded studentship (unfunded). Applicants must secure their own funding; possible sources mentioned include Gates Cambridge Trust and Cambridge Trust. Please check the postgraduate funding competition box when applying.

Eligibility: Open to students worldwide, subject to University of Cambridge eligibility criteria and successful admission. Incomplete applications will not be considered, and visa application is only possible after an unconditional offer is issued.

Deadline: 8 December 2027. Interviews are expected in the week commencing 18 January 2027.

Funding details

Competition funded studentship (unfunded). Applicants must apply for their own funding; possible sources mentioned include University of Cambridge-wide funding competitions such as Gates Cambridge Trust and Cambridge Trust.

What's required

Applicants must meet all University of Cambridge eligibility criteria and secure admission to the University. The project is open to students worldwide, but candidates must arrange their own funding and may need to satisfy visa requirements before taking up the award. Incomplete applications will not be considered.

How to apply

Register interest via the FindAPhD project page and ensure you check the postgraduate funding competition box when applying. You must also apply for admission to the University of Cambridge and secure funding separately.

More information can be found here

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