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MRC Laboratory of Medical Sciences

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Funded PhD in Spatial and Three-Dimensional Genome Regulation During Zygotic Genome Activation MRC Laboratory of Medical Sciences in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

Funded PhD studentship covering all tuition fees plus a tax-free stipend of £26,500 per year paid monthly. Funding is available for both Home and Overseas students.

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Country

United Kingdom

University

MRC Laboratory of Medical Sciences

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Keywords

Molecular Biology
Biology
Genetic
Genomic
Bioinformatic

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About this position

Funded PhD opportunity at the MRC Laboratory of Medical Sciences (LMS) in London, United Kingdom, on spatial and three-dimensional genome regulation during zygotic genome activation (ZGA).

This project explores how chromatin architecture, promoter-enhancer communication, boundary formation, insulation, and spatially restricted transcriptional states are coordinated as the embryonic genome becomes active. The work sits at the intersection of developmental genomics, chromatin biology, genomics, genetics, bioinformatics, and molecular biology.

The project is jointly associated with Dr J Vaquerizas and Dr Andrew Russell. It will combine low-input chromosome conformation methods such as Pico-C with spatially resolved genomics approaches including Slide-tags, and may also use Xenium-based imaging and long-read sequencing depending on the chosen biological question. The student will work with multimodal datasets at single-cell or single-nucleus resolution and may investigate isoform usage, haplotype-resolved transcription, or allele-specific regulation in embryonic contexts.

Funding: full tuition fees plus a tax-free stipend of £26,500 per year. Funding is available for both Home and Overseas students.

How to apply: Apply via the LMS studentships webpage and submit the required application form. The FindAPhD “register your interest” button is not the application.

Funding details

Funded PhD studentship covering all tuition fees plus a tax-free stipend of £26,500 per year paid monthly. Funding is available for both Home and Overseas students.

What's required

The project is aimed at a PhD student and sits at the interface of developmental genomics, chromatin biology and spatial omics. The student should be interested in integrative analysis of multimodal datasets at single-cell or single-nucleus resolution, with a balance of experimental and computational work depending on project direction. The post does not list specific degree, GPA, or language-test requirements.

How to apply

Follow the application instructions on the LMS studentships webpage and submit an application form by the deadline. Registering interest on FindAPhD is not considered an application.

More information can be found here

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