University of Oxford
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1 week ago
Funded PhD in Precision RNA Editing Platforms for Therapeutic Applications University of Oxford in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Funded PhD project. The MRC CoRE-TG DPhil scholarship, if awarded, covers course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. The project is described as a funded PhD project for students worldwide, but the named scholarship is limited to UK national students.
Deadline
Dec 1, 2026
Country
United Kingdom
University
University of Oxford
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About this position
PhD opportunity at the University of Oxford in the Department of Paediatrics on developing a precision RNA editing platform for therapeutic applications.
This funded DPhil project focuses on RNA editing, antisense oligonucleotides (ASOs), genetics, genomics, molecular biology, molecular genetics, and cell biology. The project aims to identify disease-causing mutations amenable to RNA editing, engineer ASO conjugates that target endogenous RNA editors, and test lead candidates in reporter cell lines and disease models such as iPSC-derived neurons. Optional in vivo work in mice may also be available.
Research methods include molecular cloning, protein engineering, vector design, linker optimization, protein expression and purification, nucleic acid synthesis and modification, cell culture, transfection, RT-PCR, sequencing-based editing analysis, and bioinformatics for off-target and efficiency assessment.
The project is supervised by Prof Carlo Rinaldi and Prof Stephan Sanders at the University of Oxford. A collaboration with the Rosalind Franklin Institute in Harwell (Oxfordshire) is mentioned, including an opportunity to visit the Discovery Platform during the first year.
Funding information states that applicants may be nominated for an MRC CoRE-TG DPhil scholarship, which provides course fees, a UKRI-rate stipend for four years, a £20,000 RTSG, and a £1,200 travel allowance. The scholarship is restricted to UK national students because of UKRI limits on international recruitment.
Applications are competitive and will be assessed according to the admissions requirements of the relevant host department or university. Interested candidates should register their interest via the FindAPhD listing and contact the programme email for scholarship queries.
Funding details
Funded PhD project. The MRC CoRE-TG DPhil scholarship, if awarded, covers course fees for the duration of fee liability, a living stipend at the UKRI rate for four years, a £20,000 Research Training Support Grant, and a £1,200 travel allowance. The project is described as a funded PhD project for students worldwide, but the named scholarship is limited to UK national students.
What's required
Applicants should have or be expected to obtain a relevant background for a DPhil/PhD project in the life sciences, with interest in RNA editing, antisense oligonucleotides, molecular cloning, protein engineering, cell culture, transfection, sequencing-based analysis, and bioinformatics. The post notes that applications will be assessed according to the admissions requirements of the relevant host department or university. UK national students are eligible for the MRC CoRE-TG DPhil scholarship; international students are not eligible for that scholarship due to UKRI limits.
How to apply
Register your interest for the project through the FindAPhD page and complete the enquiry form. For scholarship questions, contact [email protected]. Applications will be assessed under the host department or university admissions requirements.
More information can be found here
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