Eisbach Bio GmbH
3 weeks ago
PhD Fellow Position (MSCA Doctoral Network HubMOL DC7) at Eisbach Bio GmbH Eisbach Bio GmbH in Germany
Degree Level
PhD
Field of study
Biochemistry
Funding
Available
Deadline
Sep 13, 2026
Country
Germany
University
Eisbach Bio GmbH
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About this position
PhD Fellow position in the EU-funded MSCA Doctoral Network HubMOL (DC7) at Eisbach Bio GmbH, Germany.
This call is for a PhD researcher to join HubMOL – Hub Molecules of Metabolism and Signalling: Key regulators of Life, a Horizon Europe Marie Skłodowska-Curie Actions doctoral network with 16 PhD positions across Europe. The project combines leading academic and industrial expertise in epigenetics, mathematical modelling, and stable-isotope-based analysis to study metabolic cofactors and post-translational modifications. The broader network focuses on key hub molecules such as ATP, NAD, CoA, FAD, and SAM, and aims to develop knowledge-based nutritional intervention strategies.
Host organisation: Eisbach Bio GmbH, based in Planegg/Martinsried near Munich, Germany, is a biotechnology company working in drug discovery and development, with particular emphasis on chromatin remodeling enzymes, DNA repair pathways, and synthetic lethality in cancer therapy. The company’s platform uses allosteric approaches to identify and validate vulnerabilities in cancer cells and to develop next-generation precision oncology treatments.
Project focus for DC7: The advertised PhD topic investigates the synergy between HPF1-mediated serine ADP-ribosylation of chromatin and ALC1 chromatin remodeller function in DNA-damage-mediated, NAD-dependent activation of PARP1/2. The work aims to: (1) dissect the functions and biological roles of ALC1 and HPF1 in PARP1/2-mediated DNA damage responses; (2) determine the role of HPF1 in NAD-dependent and poly(ADP-ribose)-mediated recruitment of ALC1 to DNA damage sites; and (3) establish the mechanism of PARP inhibitor sensitization mediated by ALC1 and HPF1, individually and together.
Supervisor: Andreas Ladurner ([email protected]).
Funding: The position is funded through Horizon Europe MSCA. The announcement states a gross annual salary of EUR 42,000, plus a family allowance of EUR 7,200 per year if applicable.
Eligibility highlights: Candidates should hold a Master’s degree or equivalent in molecular biology, cell biology, cancer biology, biochemistry, biophysics, biomedicine, analytical chemistry, or a related field. A bioinformatics background may also be suitable with strong biochemistry knowledge. Applicants should have excellent English, high motivation, strong communication and teamwork skills, and relevant experience in chromatin biology, DNA damage repair, epigenetics, molecular cloning, cell culture, biochemical assays, and ideally protein purification, CRISPR/Cas9, advanced microscopy, or omics methods.
Mobility rule: Applicants must be doctoral candidates, not already holding a PhD, and must satisfy MSCA mobility requirements, including transnational relocation and the rule that they have not lived or carried out their main activity in Germany for more than 12 months in the 3 years before the reference date (with stated refugee exceptions).
Application: Apply by email to [email protected] by 13 September 2026. The selection process includes expert assessment of written applications followed by a two-stage interview for shortlisted candidates.
More information: HubMOL project website: www.hubmol.eu. Host organisation website: www.eisbach.bio.
Funding details
Available
What's required
Applicants must have a Master’s degree or equivalent in molecular biology, cell biology, cancer biology, biochemistry, biophysics, biomedicine, analytical chemistry, or a closely related field; bioinformatics candidates are considered if they have a good understanding of biochemistry. A strong background or prior knowledge in hub-molecule-related topics is required, along with relevant expertise in cell metabolism and related HubMOL areas. The post requires excellent English speaking and writing skills, high motivation, strong collaborative and communication skills, and a documented interest in precision oncology and novel drug targets. Preferred experience includes chromatin biology, DNA damage repair, or epigenetics, plus skills in protein expression/purification, CRISPR/Cas9 gene editing, advanced microscopy, molecular cloning, cell culture, biochemical assays, and omics approaches such as proteomics or transcriptomics. Applicants must be doctoral candidates at the time of recruitment, not already holding a doctoral degree, and must meet the doctorate admission requirements of the host institution. Mobility-rule eligibility applies: candidates must relocate across countries and must not have resided or carried out their main activity in Germany for more than 12 months in the 3 years before the reference date, unless exempt as a refugee under the stated rules.
How to apply
Send your application by email to [email protected]. Use the position subject line when applying and include the materials required by the doctoral network and host institution. Applications are reviewed by an expert committee, and shortlisted candidates will be invited to a two-stage interview process.
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