PhD in Epithelial Mechanobiology – Desmosomal Dysfunction and Plexin Regulation Philipps-University Marburg in Germany

Philipps-University Marburg, renowned for its rich academic tradition and award-winning teaching, is offering a fully funded PhD position in Epithelial Mechanobiology within the Faculty of Medicine, Institute of Pharmacology. The research group led by Prof. Dr. Thomas Worzfeld is seeking a motivated doctoral candidate to join a dynamic, international team and contribute to cutting-edge research on the molecular regulation of desmosomes in epithelial tissues.

This project is part of the Transregional Collaborative Research Centre 425 “Desmosomal dysfunction in epithelial barriers” (DEFINE), funded by the German Research Foundation (DFG). The research aims to elucidate the mechanisms underlying desmosome regulation, focusing on plexins—a family of transmembrane receptors—and their role in health and disease, particularly in pemphigus, a severe autoimmune skin disorder. The work will involve a range of advanced techniques, including protein crosslinking, affinity purification, mass spectrometry, cultures of primary keratinocytes, skin organoids, mechanobiology methods, advanced imaging, and analyses of preclinical mouse models (FACS, histology).

Applicants should hold an M.Sc. degree or equivalent in a Life Sciences subject and demonstrate high motivation, creativity, and team spirit. Excellent written and spoken English skills are required. Experience in biochemical methods, cellular and molecular biology, mechanobiology, advanced imaging, animal experiments, and histology is advantageous. The position offers a competitive salary and benefits (TV-H E 13, 65%), access to state-of-the-art infrastructure, international research networks, comprehensive training and mentoring, and free use of public transportation in Hessen.

The university actively supports the professional development of junior researchers through Marburg Research Academy (MARA), the International Office, and the Higher Education Didactics Office. The position is limited to three years, in accordance with German academic contract regulations, and is intended for completion of a doctoral degree. Philipps-University Marburg is certified as a family-friendly institution and encourages applications from women, parents, and individuals with disabilities. Flexible working arrangements are possible.

To apply, submit your application via the Nature Careers portal. Ensure you meet the eligibility requirements and prepare all necessary documents. Applications are accepted until the position is filled. For further information, visit the Institute of Pharmacology or the DEFINE project websites.