International PhD Programme (IPP) Mainz, Institute of Molecular Biology
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PhD Position: Deciphering the disorder-mediated interactome of the BAF-associated ARID proteins with implications in colorectal cancer (m/f/d) International PhD Programme (IPP) Mainz in Germany
Degree Level
PhD
Field of study
Biology
Funding
Available
Deadline
Oct 15, 2026
Country
Germany
University
International PhD Programme (IPP) Mainz, Institute of Molecular Biology
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About this position
International PhD Programme (IPP) Mainz at the Institute of Molecular Biology is offering a fully funded PhD position in an interdisciplinary life-science environment in Mainz, Germany.
The project, supervised by Katja Luck, is titled “Deciphering the disorder-mediated interactome of the BAF-associated ARID proteins with implications in colorectal cancer”. It sits at the interface of chromatin biology, genome maintenance, structural proteomics, and cancer research. The work focuses on BAF chromatin-remodeling complexes and their subtype-determining ARID subunits, which are linked to distinct cellular vulnerabilities and cancer-relevant phenotypes. A key question is how the intrinsically disordered regions of these very large proteins mediate protein-protein interactions and regulate DNA repair and cell cycle processes.
The PhD candidate will use experimental and computational approaches, including novel NGS-based methods, structural proteomics, AlphaFold-based structure prediction, and in-house software tools to identify interaction partners and map interaction interfaces. The project also involves validation in CRISPR-engineered cell lines and, where relevant, further functional work in the context of colorectal cancer and colon organoids. The project is embedded in the collaborative research consortium SFB1361, pending a funding decision in November 2026.
This PhD opportunity is part of the International PhD Programme (IPP) Mainz, which offers advanced training, a lively international community, and access to state-of-the-art core facilities. English is the working language. The programme highlights a strong research training environment with more than 200 PhD students from many countries.
Eligibility highlights include a Master’s degree or equivalent, good English, an interactive personality, and two reference letters. The application deadline is 15 October 2026. Interviews are planned for 18-19 January 2027 at IMB in Mainz. The expected start date is between 1 February and 31 July 2027.
Applicants interested in this project should select Luck (BAF) as their group preference in the IPP application platform and apply online via the official application page.
Funding details
Available
What's required
Master's degree or equivalent in a relevant field, good command of English, an interactive personality, and two letters of reference are required. The description emphasizes an ambitious scientist with interest in interdisciplinary research; no specific GPA or test score is mentioned.
How to apply
Select "Luck (BAF)" as your group preference in the IPP application platform. Submit the online application via the apply website and ensure your application is completed before 15 October 2026. Prepare two letters of reference as part of the application materials.
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