European Synchrotron Radiation Facility (ESRF)
1 week ago
PhD Probing conformational membrane protein dynamics by time-resolved X-ray solution scattering European Synchrotron Radiation Facility (ESRF) in France
Degree Level
PhD
Field of study
Chemistry
Funding
Available
Deadline
Oct 15, 2026
Country
France
University
European Synchrotron Radiation Facility (ESRF)
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About this position
PhD opportunity at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France, on probing conformational membrane protein dynamics by time-resolved X-ray solution scattering (TR-XSS).
You will join the ID09 team at the ESRF, an international research centre known for ultrabright X-ray beams and ultrafast X-ray science. The project focuses on two biologically and medically important membrane proteins: the zinc-transporting ATPase SsZntA and the dopamine D2 receptor. Using laser-triggered caged compounds, you will initiate ATP- and ligand-driven reactions and track structural changes from milliseconds to seconds to understand how these proteins function at the molecular level.
A key part of the project is methodological development: you will help improve TR-XSS workflows to extend the accessible time range and reduce sample consumption. This is especially valuable for challenging membrane proteins that are slow, complex, or difficult to produce in large quantities. The work combines advanced synchrotron experiments, time-resolved structural biology, analysis of dynamic molecular processes, and method development at a world-leading large-scale facility.
The position is hosted by the European Synchrotron Radiation Facility in Grenoble and is linked to Umeå University, where you will be enrolled in the Doctoral School as a condition of recruitment. The ESRF offers an inclusive international environment, competitive compensation and allowances, and relocation support to Grenoble.
Eligibility highlights: a degree enabling PhD enrolment in chemistry, physics, molecular biology, or a related field; a background in biophysics is desirable; strong English proficiency; compliance with the Marie Skłodowska-Curie mobility rule; and proof of diploma at application. Applicants must be doctoral candidates and not already hold a PhD.
Application: apply through the online link provided. The deadline stated in the description is 15 October 2026.
Funding details
Available
What's required
Degree allowing enrollment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in chemistry, physics, molecular biology or a closely related science is required. A background in biophysics is desirable. Proficiency in English is required. Candidates must satisfy the conditions for enrolment in a doctoral programme, be doctoral candidates and not already hold a doctoral degree, and provide proof of the diploma at the time of application. Candidates must also comply with the Marie Skłodowska-Curie mobility rule: they may not have resided or carried out their main activity in the host institute's country for more than twelve months in the three years immediately before the application deadline of 15 October 2026.
How to apply
Apply via the provided application link. Shortlisted candidates will later be invited to apply for the relevant Umeå PhD programme. Ensure you can document your qualifying degree and eligibility under the MSCA mobility rule.
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