CNRS
4 days ago
Postdoctoral Position in RNA and Translation at CNRS / I2BC CNRS in France
Degree Level
Postdoc
Field of study
Biochemistry
Funding
Temporary full-time postdoctoral contract funded through the EU Research Framework Programme (Horizon Europe - ERC) within the ERC Synergy project 3Stops2go.
Deadline
Oct 23, 2026
Country
France
University
CNRS

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About this position
Postdoctoral position in RNA and translation at CNRS / Institut de Biologie Intégrative de la Cellule (I2BC), Gif-sur-Yvette, France.
This opening is for a postdoctoral researcher to join the ERC Synergy project 3Stops2go, focused on engineering alternative decoding for therapeutic purposes. The work sits at the intersection of RNA, translation, biochemistry, biophysics, and biological engineering.
The project has two main goals: (1) designing and analysing a large-scale screen in human cells to identify suppressor tRNAs that can efficiently read through premature termination codons while remaining selective for native stop codons; and (2) elucidating the mechanism of action of TLN468 and its derivatives, a readthrough inducer with unusual selectivity. The successful candidate will contribute to quantitative reporter design, functional screening, high-throughput data analysis (NGS and ribosome profiling), and mechanistic interpretation.
Planned activities include molecular biology (cloning, expression, in vitro transcription and translation), biochemical work (protein purification, luciferase assays), human cell culture, lentivirus handling, and development of a lentivirus-based screen for tRNA optimisation. The position is based at I2BC (CEA, CNRS, Université Paris-Saclay) in the Génomique, Structure et Traduction team, with access to sequencing, flow cytometry, mass spectrometry, cryo-EM, and the broader Paris-Saclay research environment.
Eligibility highlights: PhD or equivalent in molecular biology, biochemistry, or a related field; strong expertise in RNA and translation; experience with cloning, human cell culture, flow cytometry, and NGS analysis; lentiviral vectors, functional screens, or ribosome profiling are advantageous. Basic French is listed, and strong scientific English plus autonomy, rigour, initiative, and teamwork are expected.
Funding and contract: temporary full-time postdoctoral contract, 35 hours/week, funded through Horizon Europe - ERC. Start date is listed as 1 Dec 2026.
Deadline: 23 Oct 2026, 23:59 UTC.
Funding details
Temporary full-time postdoctoral contract funded through the EU Research Framework Programme (Horizon Europe - ERC) within the ERC Synergy project 3Stops2go.
What's required
A PhD or equivalent in molecular biology, biochemistry or a related field is required. Candidates should have solid expertise in RNA and translation, and strong skills in cloning, human cell culture, flow cytometry, and NGS data analysis. Experience with lentiviral vectors, functional screens, or ribosome profiling is a significant asset. Basic French is listed, and good scientific English, autonomy, rigour, initiative, and collaborative ability are expected.
How to apply
Apply via the CNRS job portal or the Euraxess listing. Review the full job details, then submit your application through the official application website.
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