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Daniel Humphreys

Just Landed

2 days ago

Fully Funded BBSRC PhD Studentship in Typhoidal Salmonella Host-Pathogen Interactions and Immune Evasion University of Sheffield in United Kingdom

Degree Level

PhD

Field of study

Immunology

Funding

Fully funded four-year BBSRC YBDTP PhD studentship. The post does not state the stipend amount or specific tuition-fee arrangements.

Deadline

Jan 6, 2027

Country flag

Country

United Kingdom

University

University of Sheffield

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Keywords

Immunology
Microbiology
Biology
Infectious Disease
Antibiotic Resistance
Medical Science
Host-pathogen Interaction
Drug Screening

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About this position

The University of Sheffield is offering a fully funded four-year PhD studentship in host-pathogen interactions, microbiology and immune evasion. The project, titled “How does typhoidal Salmonella remain invisible to the human immune system?”, will investigate how antimicrobial-resistant Salmonella Typhi causes typhoid fever while evading host immune defences.

The research focuses on a proposed mechanism involving secreted typhoid toxin. Preliminary data indicate that the toxin may act as a cell-cycle-dependent executioner of immune cells programmed to attack Salmonella, contributing to pathogen persistence and typhoid disease. The student will explore how this process affects immune-cell survival and host-pathogen interactions.

This interdisciplinary project combines immunology with molecular microbiology and incorporates high-dimensional spectral flow cytometry, timsTOF phosphoproteomics, live-cell imaging and drug screening during infection. The supervisory team comprises Daniel Humphreys and Mark Collins at the University of Sheffield, Sherif El-khamisy at the University of Bradford, and Dave Boucher at the University of York. The collaboration provides a research environment spanning three UK universities and complementary expertise in infection biology, immune responses and molecular mechanisms of disease.

Funding details

Fully funded four-year BBSRC YBDTP PhD studentship. The post does not state the stipend amount or specific tuition-fee arrangements.

What's required

Open to UK (Home) and International/EU students. The post does not specify additional academic, technical or language-test requirements; candidates are invited to contact Daniel Humphreys for informal enquiries.

How to apply

Review the FindAPhD advert and application details, then submit an application by 6 January 2027 at 5:00 PM UK time. Contact Daniel Humphreys at [email protected] for informal enquiries.

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Professors

Senior Lecturer & UKRI Future Leaders Fellow

University Name
Country flag

United Kingdom

Research Interests

Microbiology

Immunology

Host-pathogen Interaction

Infectious Disease

Anti-aging Research