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Daniel Humphreys
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2 days ago
Fully Funded BBSRC PhD Studentship in Typhoidal Salmonella Host-Pathogen Interactions and Immune Evasion University of Sheffield in United Kingdom
Degree Level
PhD
Field of study
Immunology
Funding
Fully funded four-year BBSRC YBDTP PhD studentship. The post does not state the stipend amount or specific tuition-fee arrangements.
Deadline
Jan 6, 2027
Country
United Kingdom
University
University of Sheffield
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About this position
The University of Sheffield is offering a fully funded four-year PhD studentship in host-pathogen interactions, microbiology and immune evasion. The project, titled “How does typhoidal Salmonella remain invisible to the human immune system?”, will investigate how antimicrobial-resistant Salmonella Typhi causes typhoid fever while evading host immune defences.
The research focuses on a proposed mechanism involving secreted typhoid toxin. Preliminary data indicate that the toxin may act as a cell-cycle-dependent executioner of immune cells programmed to attack Salmonella, contributing to pathogen persistence and typhoid disease. The student will explore how this process affects immune-cell survival and host-pathogen interactions.
This interdisciplinary project combines immunology with molecular microbiology and incorporates high-dimensional spectral flow cytometry, timsTOF phosphoproteomics, live-cell imaging and drug screening during infection. The supervisory team comprises Daniel Humphreys and Mark Collins at the University of Sheffield, Sherif El-khamisy at the University of Bradford, and Dave Boucher at the University of York. The collaboration provides a research environment spanning three UK universities and complementary expertise in infection biology, immune responses and molecular mechanisms of disease.
Funding details
Fully funded four-year BBSRC YBDTP PhD studentship. The post does not state the stipend amount or specific tuition-fee arrangements.
What's required
Open to UK (Home) and International/EU students. The post does not specify additional academic, technical or language-test requirements; candidates are invited to contact Daniel Humphreys for informal enquiries.
How to apply
Review the FindAPhD advert and application details, then submit an application by 6 January 2027 at 5:00 PM UK time. Contact Daniel Humphreys at [email protected] for informal enquiries.
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Professors
Senior Lecturer & UKRI Future Leaders Fellow
United Kingdom
Research Interests
Microbiology
Immunology
Host-pathogen Interaction
Infectious Disease
Anti-aging Research
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Prepare your application
Review drafts and confirm requirements with the university.