University of Bristol
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4 days ago
Funded PhD in PINK1 mitochondrial quality control and Parkinson’s disease University of Bristol in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Funded through the GW4 BioMed3 MRC Doctoral Landscape Programme. Funding includes UK tuition fees, a Doctoral Stipend matching the UK Research Council National Minimum (£21,805 p.a. for 2026/27, updated each year), plus additional research training and support funding of up to £5,000 per annum.
Deadline
Oct 21, 2026
Country
United Kingdom
University
University of Bristol

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About this position
Funded PhD project at the University of Bristol in the School of Biochemistry and Biomedical Sciences on PINK1, mitochondrial quality control, and Parkinson’s disease.
The project, supervised by Prof I Collinson and Dr Robin Corey, investigates how PINK1 switches between alternative fates in mitochondria: matrix import versus cleavage/retro-translocation and outer-membrane activation. The research combines biochemistry, biophysics, cell biology, and computational modelling to study the conformational switch in the PINK1 transmembrane domain, its interactions with PARL and the TIM23 import machinery, and the consequences of PINK1 in the mitochondrial matrix.
Planned work includes analysing disease-relevant PINK1 variants, examining mitochondrial function after matrix exposure or depletion of PINK1, and attempting to control PINK1 destiny using small molecules or protein reagents. The project is designed to generate new insight into mitochondrial structure, function, and neurodegeneration, with potential relevance to therapeutic intervention in early-onset Parkinson’s disease.
This is a funded PhD project open to students worldwide. Funding covers UK tuition fees, a UKRI-aligned stipend, and additional research training/support funding. The application deadline is 21 October 2026. Applicants should apply via the GW4 BioMed website and may select up to two projects.
Funding details
Funded through the GW4 BioMed3 MRC Doctoral Landscape Programme. Funding includes UK tuition fees, a Doctoral Stipend matching the UK Research Council National Minimum (£21,805 p.a. for 2026/27, updated each year), plus additional research training and support funding of up to £5,000 per annum.
What's required
Applicants should be interested in an interdisciplinary PhD combining computational methods with biochemical, biophysical, and cell biology techniques. The project mentions design and optimisation of experimental protocols, computational modelling and simulations, selection and characterisation of disease-relevant PINK1 variants, and data interpretation. No specific degree class, language test, or prior experience requirements are stated in the post.
How to apply
Check the GW4 BioMed website for the list of projects and application instructions. Select up to two projects and submit one application per candidate. Complete the online application form for an offer of funding by 5:00pm on Wednesday, 21 October 2026.
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