PhD in Structure-Function Analysis of Stress Signaling and Integrated Stress Response Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity at the University of St Andrews in the School of Biology: EastBIO: Understanding human sulfatases involved in heparan sulfate degradation . This project sits at the intersection of biochemistry , molecular biology , structural biology , biophysics , and biomedical engineering . The research focuses on human lysosomal sulfatases that act on heparan sulfate, with the goal of understanding their structure, mechanism, function, and disease relevance . The work connects directly to ly...

PhD opportunity at the University of Dundee in the Faculty of Life Sciences on the project EASTBIO - Uncovering the non-canonical proteolytic activity of Deubiquitinating enzymes . This discovery-driven PhD sits at the interface of biochemistry , structural biology , cell biology , biophysics , and proteomics . The project focuses on ubiquitin-deconjugating enzymes (DUBs), especially the USP family, and their newly identified non-canonical “cleave-to-modify” activity. The research aims to define...

PhD opportunity in Protein Aggregates and Neurodegeneration at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with Dr H McMahon. This project explores how protein aggregates accumulate, become toxic to brain cells, and spread in neurodegenerative disease. Two related PhD projects are available in the McMahon group. One focuses on aggregate uptake mechanisms , including Aggregation-Dependent Endocytosis, receptor identification, aggregate size effects, and ways to prev...

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

Weill Cornell Medicine is advertising a Postdoctoral Associate in Biochemistry & Biophysics in the Reck-Peterson Lab , focused on the mechanisms of intracellular transport across molecular, cellular, and organismal scales. The project areas include: (1) how defects in intracellular transport contribute to neurodegenerative disease , with emphasis on LRRK2 and Parkinson’s disease ; (2) mechanisms of organelle “hitchhiking” in filamentous fungi and their implications for secondary metabolite produ...