Medical Research Council (Cambridge)
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PhD in Structure-Function Analysis of Stress Signaling and Integrated Stress Response Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Competition funded PhD project. Funding details beyond this are not specified in the post.
Deadline
Dec 8, 2026
Country
United Kingdom
University
Medical Research Council (Cambridge)

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About this position
PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti.
The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS).
Research themes include characterising novel regulatory mechanisms governing ISR components using cell biology, biochemistry, genetics, and proteomics, as well as investigating the structural basis of key ISR components through biochemical approaches, structural proteomics, and cryo-electron microscopy (cryo-EM). The broader lab program is multidisciplinary, combining chemistry, biochemistry, biophysics, structural biology, cell biology, and mouse models.
This is a competition-funded PhD project for students worldwide. The post does not list a specific stipend amount, tuition package, or formal eligibility thresholds in the text provided.
To apply, register your interest on the FindAPhD project page and complete the enquiry form. The university will respond directly, and you can use the page to ask questions about applications, funding, and eligibility.
Funding details
Competition funded PhD project. Funding details beyond this are not specified in the post.
What's required
Applicants should be interested in multidisciplinary research spanning chemistry, biochemistry, biophysics, structural biology, cell biology, genetics, proteomics, cryo-EM, and mouse models of disease. The project is advertised as a competition-funded PhD project for students worldwide; no specific degree class, language test, or GPA requirement is stated in the post.
How to apply
Register your interest through the FindAPhD page and submit the enquiry form with your contact details. The university will respond directly to you by email. Use the project page to ask questions about applications, funding, or eligibility.
More information can be found here
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