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Instituto de Investigaciones Biomédicas Alberto Sols
5 days ago
PhD in Cancer Immunotherapy, CAR-T Cell Engineering and Translational Cancer Research Instituto de Investigaciones Biomédicas Sols-Morreale CSIC & UAM in Spain
Degree Level
PhD
Field of study
Immunology
Funding
A four-year predoctoral contract is offered with a total value of €32,500, including salary and social security costs.
Deadline
Nov 22, 2026
Country
Spain
University
Instituto de Investigaciones Biomédicas Alberto Sols
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About this position
This PhD project develops new immunotherapeutic tools for cancers with poor prognosis, with a focus on next-generation cellular immunotherapy and CAR T-cell platforms. The research will include the development of lentiviral vectors for TRUCKs whose expression is regulated by the tumor microenvironment, as well as studies of immune-synapse modulation to improve the effector function and persistence of CAR T cells.
The project addresses refractory or relapsed B-cell malignancies, including aggressive pediatric cancers, and combines cancer immunology, molecular and cellular engineering, tumor biology, advanced microscopy, and clinically relevant preclinical models. Its translational orientation is strengthened by the use of an original fourth-generation CAR platform, clinically validated CAR components, and collaboration with researchers who have clinical expertise.
The student will be based in the host IIBM-CSIC laboratory and will participate in the Next Generation ImmunoTherapy Madrid consortium, a joint initiative involving basic and clinical groups. The research environment provides access to advanced flow cytometry, confocal and STED microscopy, in vivo imaging, animal facilities, high-field MRI, genomic facilities, and other state-of-the-art technologies.
The PhD student will join a multidisciplinary setting at the interface of cancer immunology, cellular engineering, and translational medicine, with interaction among basic and clinical researchers. The consortium supports collaborative activities, seminars, research stays, conferences, and international scientific collaborations. Doctoral studies will be undertaken through the Molecular Biosciences PhD Program at the Autonomous University of Madrid.
Funding details
A four-year predoctoral contract is offered with a total value of €32,500, including salary and social security costs.
What's required
Applicants need a strong academic record, previous research experience, and a background in immunology, cancer biology, molecular or cellular biology, hematology, or a related field. A bachelor's degree or equivalent in Biology, Biochemistry, Biotechnology, Biomedicine, Medicine, Pharmacy, or a related discipline is required, together with a completed or expected master's degree or equivalent qualification providing access to doctoral studies before the position starts. Candidates must be eligible for admission to the corresponding doctoral programme in Spain, have good written and spoken English, and demonstrate interest in biomedical research. Experience with cell culture, flow cytometry, microscopy, molecular biology, functional cellular assays, animal models, CAR-T/CAR-NK cells, immune-cell engineering, primary human cells, or preclinical cancer models is valued. Publications, conference presentations, awards, research stays, analytical and problem-solving skills, teamwork, and motivation for translational cancer research are also considered.
How to apply
Apply by email to [email protected], using the required Euraxess PhD position application form and supporting materials. The application deadline is 22 November 2026 at 15:00 Europe/Madrid time. The position can also be accessed through the Euraxess application page.
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