PhD in Co-transcriptional Splicing Using Cryo-EM and Biochemistry MRC Laboratory of Molecular Biology in United Kingdom

Funded PhD project at The Francis Crick Institute in London, United Kingdom, on the cryo-EM structure of mechanically unfolded proteins . The project is a 2027 Crick Joint PhD with Dr Sergi Garcia-Manyes and Dr Alessandro Costa , combining expertise from single-molecule mechanics and cryo-EM. The research sits at the intersection of biochemistry , biophysics , physical chemistry , molecular biology , and bioengineering . It focuses on how mechanical forces regulate protein unfolding and mechanot...

PhD opportunity at The Francis Crick Institute, London, United Kingdom in structural biology, virology, biochemistry, biophysics, and molecular biology . This funded PhD project, supervised by Dr I Taylor , focuses on the ZAP antiviral response and how the proteins ZAP, KHNYN, and Trim25 assemble into molecular complexes that recognize viral RNA and trigger RNA degradation. The project aims to uncover the structure and mechanism of this antiviral system using protein purification, RNA-binding as...

Postdoctoral opportunity at Columbia University in New York City, United States focused on cryo-EM , cryo-ET , malaria parasite membrane protein complexes, and host-pathogen membrane remodeling. The Ho Lab in the Department of Microbiology & Immunology at Columbia University Irving Medical Center is seeking a highly motivated Postdoctoral Fellow to study how the malarial moving junction complex assembles and remodels membranes during parasite invasion of human red blood cells. The project combin...

Two PhD positions are available at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz-FMP) in Berlin, Germany , in the Molecular Biophysics Research Unit led by Prof. Adam Lange . The project focuses on the structure, dynamics, and function of membrane proteins , including potassium channels and rhomboid proteases , using solid-state NMR and cryo-EM . The post highlights access to a 1.2 GHz NMR spectrometer and a Titan Krios cryo-EM instrument, with additional emphasis on cell-...

Funded PhD project at the University of Warwick in Coventry, United Kingdom , focused on Basidiomycota fungi , natural products biosynthesis , fungal genetic engineering , and engineering biology . The project aims to validate an engineering biology toolkit in Pleurotus ostreatus (oyster mushroom) by reconstructing biosynthetic pathways for selected bioactive natural products from Basidiomycota fungi. Research activities include cloning biosynthetic genes into expression vectors, fungal transfor...