Publisher
source

The Francis Crick Institute

PhD in Elucidating the Structure and Mechanism of the ZAP Antiviral Response The Francis Crick Institute in United Kingdom

Degree Level

PhD

Field of study

Biochemistry

Funding

Funded PhD project. Successful applicants receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.

Deadline

Nov 2, 2026

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Country

United Kingdom

University

The Francis Crick Institute

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Keywords

Biochemistry
Molecular Biology
Chemistry
Virology
Biomedical Engineering
Biophysics
Biology
Structural Biology
Cryo-electron Microscopy
Medical Science
Physics

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About this position

PhD opportunity at The Francis Crick Institute, London, United Kingdom in structural biology, virology, biochemistry, biophysics, and molecular biology.

This funded PhD project, supervised by Dr I Taylor, focuses on the ZAP antiviral response and how the proteins ZAP, KHNYN, and Trim25 assemble into molecular complexes that recognize viral RNA and trigger RNA degradation. The project aims to uncover the structure and mechanism of this antiviral system using protein purification, RNA-binding assays, RNA degradation assays, biochemical and enzymological approaches, and cryo-EM.

Research topics include protein-RNA interactions, antiviral restriction, cryo-electron microscopy, RNA specificity, and viral replication. The work has relevance for understanding human antiviral defense and for applications in gene therapy, mRNA vaccines, live attenuated vaccine design, and cancer biology.

Funding: successful applicants receive a non-taxable annual stipend of £27,715 plus university tuition fees. The project is open to students of all nationalities.

Eligibility: suitable for candidates with a background in molecular biology or biochemistry and an interest in structural biology and virology. Applicants should address the lab-specific question about their experience in structural biology and how it can help understand cellular inhibition of viral infection.

Application: submit via the FindAPhD listing for the 2027 Crick PhD project. The post is for a PhD in London, United Kingdom.

Funding details

Funded PhD project. Successful applicants receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.

What's required

Candidates should have a background in molecular biology or biochemistry and an interest in structural biology and virology. The lab asks applicants to describe any experience in structural biology and how it can contribute to understanding cellular inhibition of viral infection.

How to apply

Apply through the FindAPhD listing for the 2027 Crick PhD project. Prepare an answer to the lab-specific question about your structural biology experience and its relevance to cellular inhibition of viral infection.

More information can be found here

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