Funded PhD in Cryo-EM Structure of Mechanically Unfolded Proteins The Francis Crick Institute in United Kingdom

PhD opportunity at The Francis Crick Institute, London, United Kingdom in structural biology, virology, biochemistry, biophysics, and molecular biology . This funded PhD project, supervised by Dr I Taylor , focuses on the ZAP antiviral response and how the proteins ZAP, KHNYN, and Trim25 assemble into molecular complexes that recognize viral RNA and trigger RNA degradation. The project aims to uncover the structure and mechanism of this antiviral system using protein purification, RNA-binding as...

Karolinska Institutet is advertising a Postdoctoral Researcher in Structural Virology position in the research team led by Leo Hanke at the Department of Medicine, Solna, in Sweden . The project focuses on RNA virus biology , virus entry , replication , and immune recognition using structural biology approaches. The main methods include cryo-EM , biochemical and biophysical studies, image processing, three-dimensional reconstruction, atomic model building, and structural interpretation. The grou...

Postdoctoral opportunity at the University of Bristol in the Boyle and Woolfson labs, working on an Advanced Research + Innovation Agency funded project focused on the design and characterisation of 2D protein arrays . This is a collaborative project with partners at King's College London , including Mark Wallace , Aliaksandra Rakovich , and Wayne Dickson . The post specifically highlights candidates with expertise in microfluidics , photonics , single-molecule microscopy , and single-channel re...

PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti. The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease,...

Two PhD positions are available at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz-FMP) in Berlin, Germany , in the Molecular Biophysics Research Unit led by Prof. Adam Lange . The project focuses on the structure, dynamics, and function of membrane proteins , including potassium channels and rhomboid proteases , using solid-state NMR and cryo-EM . The post highlights access to a 1.2 GHz NMR spectrometer and a Titan Krios cryo-EM instrument, with additional emphasis on cell-...