PhD in Decoding Neurodevelopmental Disorders: From Patient Variants to Disease Mechanisms University of Bath in United Kingdom

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD opportunity at the University of Bath in peptide design, TFEB activation, autophagy, lysosome biology, neurodegeneration, biochemistry, biophysics, cell biology, molecular biology, structural biology, and neuroscience . This project is part of the GW4 BioMed3 MRC Doctoral Landscape Programme (DLP) , which offers up to 17 studentships for entry in September 2026 . The project asks whether designed peptides can directly activate TFEB , a key regulator of cellular waste clearance, to improve re...

PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti. The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease,...

Funded PhD project at The Francis Crick Institute in collaboration with University College London : Mechanically Induced Gene Regulatory Networks Driving Neural Crest Lineage Switching . This project investigates how mechanical confinement influences neural crest cell fate decisions, shifting cells from a neurogenic programme toward a mesenchymal lineage. The work combines developmental biology , cell biology , gene regulatory networks , mechanobiology , single-cell RNA sequencing , scATAC-seq ,...

PhD opportunity in Protein Aggregates and Neurodegeneration at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with Dr H McMahon. This project explores how protein aggregates accumulate, become toxic to brain cells, and spread in neurodegenerative disease. Two related PhD projects are available in the McMahon group. One focuses on aggregate uptake mechanisms , including Aggregation-Dependent Endocytosis, receptor identification, aggregate size effects, and ways to prev...