PhD in Pathological Protein Assembly in Neurodegenerative Diseases Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity in Protein Aggregates and Neurodegeneration at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with Dr H McMahon. This project explores how protein aggregates accumulate, become toxic to brain cells, and spread in neurodegenerative disease. Two related PhD projects are available in the McMahon group. One focuses on aggregate uptake mechanisms , including Aggregation-Dependent Endocytosis, receptor identification, aggregate size effects, and ways to prev...

PhD opportunity: Lysosomal TMEM106B in brain ageing and disease at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, Cambridge, United Kingdom. This project with Dr Diana Arseni explores how the lysosomal protein TMEM106B forms amyloids in the brain in an age-dependent manner and how TMEM106B genetic variants may influence healthy ageing and disease risk in frontotemporal lobar degeneration and Alzheimer’s disease . The research is centered on lysosomal biology , brain a...

PhD opportunity at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom on structural and cellular approaches to understand microtubule motors . This project sits at the intersection of cell biology , molecular biology , and structural biology , with a strong focus on microtubule motors such as dynein and kinesin . The research asks how motors are linked to cargos and coordinated to deliver organelles, RNAs, and proteins to the correct destination, especially...

PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti. The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease,...

PhD project in the molecular architecture of neurotransmission at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project investigates chemical synapses , neurotransmitter receptors , and large synaptic protein assemblies that connect pre-synaptic release sites with post-synaptic receptors. The research is centered on the structural and functional analysis of receptor supra-molecular complexes, with emphasis on the GABAA and glutamate ligand-...