University of St Andrews
2 weeks ago
PhD in Efficacy and Mechanisms of Novel Treatments for Antibiotic-Tolerant Infections University of St Andrews in United Kingdom
Degree Level
PhD
Field of study
Biochemistry
Funding
Competition-funded 4-year PhD studentship through the EASTBIO BBSRC Doctoral Training Partnership. Funding covers a stipend at the UKRI standard rate and UK-level tuition fees; the University of St Andrews covers the Home-International fee difference.
Deadline
Nov 16, 2026
Country
United Kingdom
University
University of St Andrews
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About this position
PhD opportunity at the University of St Andrews in antibiotic tolerance, microbiology, molecular biology, biochemistry, and pharmacy.
This EASTBIO-funded doctoral project is titled Efficacy and Mechanisms of Novel Treatments for Antibiotic-Tolerant Infections and is hosted in the School of Biology at the University of St Andrews. The project is supervised by Dr Jo Hobbs and Prof Mat Upton, with collaboration from Amprologix Ltd. The research focuses on Staphylococcus aureus and the challenge of antibiotic tolerance, where bacteria survive lethal antibiotic exposure without being resistant.
The student will evaluate novel antibiotics and antimicrobial peptides, including Amprologix candidates, against tolerant bacteria using in vitro and in vivo insect infection models. The project also explores mechanism-specific strategies such as stringent response inhibitors and metabolic adjuvants, and will investigate mechanisms of action using molecular, biochemical, transcriptomic, proteomic, and metabolomic approaches.
This is a 4-year PhD studentship and is open to UK and international students. Funding covers a UKRI-standard stipend and UK-level tuition fees, with the university covering the Home-International fee difference. The student will be based mainly at St Andrews and also complete a placement at Amprologix in Plymouth.
Applicants should submit the EASTBIO application materials, complete the required survey, and apply through the University of St Andrews online portal. Two references are required, and English language evidence should be included if applicable. Enquiries about the project can be sent to [email protected]; application queries go to [email protected].
Funding details
Competition-funded 4-year PhD studentship through the EASTBIO BBSRC Doctoral Training Partnership. Funding covers a stipend at the UKRI standard rate and UK-level tuition fees; the University of St Andrews covers the Home-International fee difference.
What's required
Applicants should be suitable for a 4-year PhD studentship and complete the EASTBIO application form, equality/diversity/inclusion survey, and online University of St Andrews application. An academic qualifications document, English language qualification if applicable, and two references are required. The post is open to UK and international students; no specific degree class, GPA, or prior experience is stated in the post.
How to apply
Download and complete the EASTBIO Equality, Diversity and Inclusion survey and EASTBIO Application Form. Submit an online application through the University of St Andrews portal and select the course 'PhD with internship'. Include the required documents and send the EASTBIO reference form to your referees. Direct project queries to the supervisor and application queries to Rachel Horn.
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Review drafts and confirm requirements with the university.