Publisher
source

The Francis Crick Institute

PhD in Evolution of Novel Function Through Retrotransposable Element Exaptation The Francis Crick Institute in United Kingdom

Degree Level

PhD

Field of study

Cell Biology

Funding

Funded PhD project. Successful applicants will receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.

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Country

United Kingdom

University

The Francis Crick Institute

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Keywords

Cell Biology
Immunology
Evolutionary Biology
Cancer Biology
Biology
Transposable Elements
Genetic
Genomic
Bioinformatic

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About this position

Funded PhD project at The Francis Crick Institute with Dr George Kassiotis on evolution of novel function through retrotransposable element exaptation. The project sits at the intersection of genetics, genomics, bioinformatics, evolution, immunology, and cancer biology, focusing on how transposable elements (TEs) and retrotransposable elements (RTEs) are co-opted to create new gene functions, alternative isoforms, and disease-relevant regulatory changes.

The research background highlights the role of endogenous retroviruses, LINEs, SINEs, and other repetitive elements in shaping transcriptomes, including cancer-specific activation and immune-related effects. The project may use human cells ex vivo/in vitro and, where needed, genetically modified mouse models to study how RTE integrations influence gene function near or within affected loci.

Ideal candidates should have a background in cell biology, cancer, or immunology, and an interest in genetics/genomics and computational approaches. This is a funded PhD open to students of all nationalities. Funding includes a non-taxable annual stipend of £27,715 plus university tuition fees.

Location: London, United Kingdom. The post is for a 2027 Crick PhD project. No explicit deadline is shown in the post.

Funding details

Funded PhD project. Successful applicants will receive a non-taxable annual stipend of £27,715 plus payment of university tuition fees. Students of all nationalities are eligible to apply.

What's required

Applicants should have a background in cell biology, cancer or immunology, with an interest in genetics, genomics, and computational approaches. The project may involve human cells ex vivo and in vitro, and potentially bespoke genetically modified in vivo mouse models.

How to apply

Review the project details on FindAPhD and apply through the PhD programme/application route at The Francis Crick Institute. Prepare to address the lab-specific question about transposable elements and exaptation in your application.

More information can be found here

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