PhD in Molecular Basis of Transcriptional Regulation During Mammalian Pre-implantation Development University of Dundee in United Kingdom

PhD opportunity at The Francis Crick Institute, London, United Kingdom This funded PhD project with Dr Alessandro Costa focuses on the in situ structure of the replication machinery inside a vertebrate nucleus. The project sits at the intersection of molecular biology , biochemistry , and structural biology , with a strong emphasis on DNA replication initiation, chromatin-associated replication complexes, and the structural mechanisms that control replication once per cell cycle. The research ai...

PhD opportunity at The Francis Crick Institute, London, United Kingdom in regulatory switching of a microtubule motor-scaffold complex with Dr Sami Chaaban. This funded PhD project focuses on how microtubule motors , especially kinesins , organize microtubules and position regulatory proteins during cell division. The project asks how interactions with regulatory partners switch kinesins between functional states and how these changes shape specialized microtubule structures. Research methods in...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

Fully funded PhD project in AI protein design, structural biology, plant immunity, bioinformatics, biophysics, biochemistry, molecular biology, and plant biology at the University of Cambridge / Bentham Lab network, with co-supervision from Marc Knight . The project aims to design synthetic plant immune receptors from first principles, using generative AI tools such as RFdiffusion, ProteinMPNN and BindCraft, together with structural bioinformatics, X-ray crystallography, cryo-EM, and in planta f...

PhD opportunity in DNA repair at stalled replication forks at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project focuses on DNA repair , replication stress , and the Fanconi Anaemia (FA) pathway , with particular attention to how cells respond to DNA crosslinks and stalled replication forks. The research aims to understand the molecular mechanisms of crosslink repair and the role of the FANCD2-FANCI heterodimer and FA core complex in mai...