PhD in Regulatory Switching of a Microtubule Motor-Scaffold Complex The Francis Crick Institute in United Kingdom

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity at The Francis Crick Institute, London, United Kingdom This funded PhD project with Dr Alessandro Costa focuses on the in situ structure of the replication machinery inside a vertebrate nucleus. The project sits at the intersection of molecular biology , biochemistry , and structural biology , with a strong emphasis on DNA replication initiation, chromatin-associated replication complexes, and the structural mechanisms that control replication once per cell cycle. The research ai...

PhD opportunity at The Francis Crick Institute with Dr Peter Rosenthal on cryomicroscopy of lipid-enveloped virus entry and assembly . The project sits at the intersection of structural biology , virology , cell biology , and biophysics , with a strong emphasis on cryo-EM , cryo-ET , and related imaging/computational methods. The research aims to directly image key steps in infection by lipid-enveloped viruses such as influenza and retroviruses . Topics include virus entry, receptor binding, mem...

PhD opportunity at The Francis Crick Institute in London, United Kingdom: Enabling antibiotics discovery by targeted protein degradation with Dr Francesca Ester Morreale. This funded PhD project focuses on targeted protein degradation (TPD) in pathogenic bacteria as a new strategy for antibiotic discovery . The project will explore how to design novel antibiotic degraders and study their mechanism of action using biochemistry , biophysics , proteomics , and molecular microbiology . The lab’s bro...

PhD opportunity: In situ structural biology of cellular adaptation at The Francis Crick Institute in collaboration with University College London . This 2027 joint PhD project is supervised by Dr Peter Rosenthal (Crick) and Dr Amandine Maréchal (UCL). The project sits at the interface of structural biology , mitochondrial biology , bioenergetics , cell biology , microbiology , biochemistry , and biophysics . The research asks how cells adapt to environmental and metabolic stress by remodeling th...