PhD in Mechanism of Transcription-Coupled Splicing Medical Research Council Laboratory of Molecular Biology in United Kingdom

PhD opportunity at the University of St Andrews in the School of Biology: EastBIO: Understanding human sulfatases involved in heparan sulfate degradation . This project sits at the intersection of biochemistry , molecular biology , structural biology , biophysics , and biomedical engineering . The research focuses on human lysosomal sulfatases that act on heparan sulfate, with the goal of understanding their structure, mechanism, function, and disease relevance . The work connects directly to ly...

Fully funded PhD project in AI protein design, structural biology, plant immunity, bioinformatics, biophysics, biochemistry, molecular biology, and plant biology at the University of Cambridge / Bentham Lab network, with co-supervision from Marc Knight . The project aims to design synthetic plant immune receptors from first principles, using generative AI tools such as RFdiffusion, ProteinMPNN and BindCraft, together with structural bioinformatics, X-ray crystallography, cryo-EM, and in planta f...

PhD opportunity in DNA repair at stalled replication forks at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project focuses on DNA repair , replication stress , and the Fanconi Anaemia (FA) pathway , with particular attention to how cells respond to DNA crosslinks and stalled replication forks. The research aims to understand the molecular mechanisms of crosslink repair and the role of the FANCD2-FANCI heterodimer and FA core complex in mai...

PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti. The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease,...

PhD opportunity at Durham University in AI protein design, structural biology, plant immunity, and bioinformatics . This fully funded four-year Gatsby Sainsbury PhD project in the Department of Biosciences and the Centre for Programmable Biological Matter (CPBM) aims to design synthetic plant immune receptors from first principles. The project combines generative protein design (including RFdiffusion, ProteinMPNN, and BindCraft), structural bioinformatics, structural biology, and plant functiona...