PhD in Mechanism of Transcription-Coupled Splicing Medical Research Council Laboratory of Molecular Biology in United Kingdom

The Francis Crick Institute in London, United Kingdom is recruiting a Postdoc in the Hill Lab led by Caroline Hill . The project sits at the intersection of structural biology , Cryo-EM , crystallography , biochemistry , biophysics , and molecular biology , with a strong focus on TGF-β family signalling , SMAD complexes , and developmental signalling in health and disease. The lab studies how TGF-β family signalling pathways function in early vertebrate development and adult cells, and how they ...

PhD opportunity in DNA repair at stalled replication forks at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project focuses on DNA repair , replication stress , and the Fanconi Anaemia (FA) pathway , with particular attention to how cells respond to DNA crosslinks and stalled replication forks. The research aims to understand the molecular mechanisms of crosslink repair and the role of the FANCD2-FANCI heterodimer and FA core complex in mai...

The International PhD Programme (IPP) Mainz at the Institute of Molecular Biology in Mainz, Germany, is recruiting for a fully funded PhD position focused on the molecular interactions of the mammalian circadian clock. Hosted by the research group of Eva Wolf, the project explores how PERIOD proteins interact within PER/CRY/CK1 complexes and with partner proteins such as WDR5 and REV-ERB/ROR nuclear receptors. The research is centered on the primary and secondary feedback loops of the mammalian ...

PhD opportunity in Structure-Function Analysis of Stress Signaling at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with supervision by Dr A Bertolotti. The lab studies stress signaling and the integrated stress response (ISR), with a strong focus on how cells protect themselves from misfolded proteins and how these pathways may be harnessed to improve resilience in disease. The project is especially relevant to neurodegenerative diseases such as Alzheimer’s disease,...

PhD opportunity in Structural Biology , Molecular Biology , Biochemistry , and Human Genetics focused on the human replisome and the mechanisms of DNA replication. The project is hosted by the Medical Research Council (Cambridge) Laboratory of Molecular Biology in the United Kingdom and is supervised by Dr J Yeeles . The lab studies how the human replication machinery is assembled, how it functions during normal DNA duplication, and how it responds to obstacles such as DNA damage and protein bar...